Human Gene FLOT2 (ENST00000585169.6) from GENCODE V44
  Description: Homo sapiens flotillin 2 (FLOT2), transcript variant 2, mRNA. (from RefSeq NM_001330170)
RefSeq Summary (NM_001330170): Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000585169.6
Gencode Gene: ENSG00000132589.16
Transcript (Including UTRs)
   Position: hg38 chr17:28,879,339-28,897,733 Size: 18,395 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr17:28,880,561-28,897,574 Size: 17,014 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:28,879,339-28,897,733)mRNA (may differ from genome)Protein (428 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 202.11 RPKM in Whole Blood
Total median expression: 2192.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.40159-0.575 Picture PostScript Text
3' UTR -444.671222-0.364 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001107 - Band_7

Pfam Domains:
PF01145 - SPFH domain / Band 7 family

ModBase Predicted Comparative 3D Structure on J3QLD9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK225491 - Homo sapiens mRNA for flotillin 2 variant, clone: JTH06502.
BC017292 - Homo sapiens flotillin 2, mRNA (cDNA clone IMAGE:4907083), partial cds.
BC003683 - Homo sapiens flotillin 2, mRNA (cDNA clone MGC:5052 IMAGE:3461759), complete cds.
M60922 - Human surface antigen mRNA, complete cds.
KJ901430 - Synthetic construct Homo sapiens clone ccsbBroadEn_10824 FLOT2 gene, encodes complete protein.
JD153960 - Sequence 134984 from Patent EP1572962.
JD270672 - Sequence 251696 from Patent EP1572962.
JD157263 - Sequence 138287 from Patent EP1572962.
JD392744 - Sequence 373768 from Patent EP1572962.
JD210947 - Sequence 191971 from Patent EP1572962.
JD464320 - Sequence 445344 from Patent EP1572962.
JD047920 - Sequence 28944 from Patent EP1572962.
JD346785 - Sequence 327809 from Patent EP1572962.
JD242167 - Sequence 223191 from Patent EP1572962.
JD255281 - Sequence 236305 from Patent EP1572962.
JD232196 - Sequence 213220 from Patent EP1572962.
JD463558 - Sequence 444582 from Patent EP1572962.
JD241631 - Sequence 222655 from Patent EP1572962.
JD256145 - Sequence 237169 from Patent EP1572962.
JD477048 - Sequence 458072 from Patent EP1572962.
JD343537 - Sequence 324561 from Patent EP1572962.
JD167045 - Sequence 148069 from Patent EP1572962.
JD523983 - Sequence 505007 from Patent EP1572962.
JD306520 - Sequence 287544 from Patent EP1572962.
JD241545 - Sequence 222569 from Patent EP1572962.
JD370896 - Sequence 351920 from Patent EP1572962.
JD065244 - Sequence 46268 from Patent EP1572962.
JD493505 - Sequence 474529 from Patent EP1572962.
JD290419 - Sequence 271443 from Patent EP1572962.
JD423641 - Sequence 404665 from Patent EP1572962.
JD538486 - Sequence 519510 from Patent EP1572962.
JD561731 - Sequence 542755 from Patent EP1572962.
JD269765 - Sequence 250789 from Patent EP1572962.
JD322026 - Sequence 303050 from Patent EP1572962.
JD151270 - Sequence 132294 from Patent EP1572962.
JD256164 - Sequence 237188 from Patent EP1572962.
JD515124 - Sequence 496148 from Patent EP1572962.
JD170989 - Sequence 152013 from Patent EP1572962.
JD409687 - Sequence 390711 from Patent EP1572962.
JD386638 - Sequence 367662 from Patent EP1572962.
JD062657 - Sequence 43681 from Patent EP1572962.
CR542265 - Homo sapiens full open reading frame cDNA clone RZPDo834E0326D for gene FLOT2, flotillin 2; complete cds, incl. stopcodon.
KJ901429 - Synthetic construct Homo sapiens clone ccsbBroadEn_10823 FLOT2 gene, encodes complete protein.
BT019477 - Homo sapiens flotillin 2 mRNA, complete cds.
BT019478 - Homo sapiens flotillin 2 mRNA, complete cds.
DQ892691 - Synthetic construct clone IMAGE:100005321; FLH188919.01X; RZPDo839H0673D flotillin 2 (FLOT2) gene, encodes complete protein.
DQ895935 - Synthetic construct Homo sapiens clone IMAGE:100010395; FLH188915.01L; RZPDo839H0663D flotillin 2 (FLOT2) gene, encodes complete protein.
CR541784 - Homo sapiens full open reading frame cDNA clone RZPDo834G0730D for gene FLOT2, flotillin 2; complete cds, without stopcodon.
AB528533 - Synthetic construct DNA, clone: pF1KB5024, Homo sapiens FLOT2 gene for flotillin 2, without stop codon, in Flexi system.
CU678570 - Synthetic construct Homo sapiens gateway clone IMAGE:100019185 5' read FLOT2 mRNA.
CU677899 - Synthetic construct Homo sapiens gateway clone IMAGE:100017629 5' read FLOT2 mRNA.
JD023165 - Sequence 4189 from Patent EP1572962.
JD077553 - Sequence 58577 from Patent EP1572962.
JD020745 - Sequence 1769 from Patent EP1572962.
JD028036 - Sequence 9060 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000585169.1, ENST00000585169.2, ENST00000585169.3, ENST00000585169.4, ENST00000585169.5, hCG_1998851, J3QLD9, J3QLD9_HUMAN, NM_001330170, uc060dfx.1, uc060dfx.2
UCSC ID: ENST00000585169.6
RefSeq Accession: NM_001330170
Protein: J3QLD9

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.