Human Gene ZNF431 (ENST00000594425.5) from GENCODE V44
Description: zinc finger protein 431 (from HGNC ZNF431) RefSeq Summary (NR_138053): This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000594425.5 Gencode Gene: ENSG00000196705.8 Transcript (Including UTRs) Position: hg38 chr19:21,142,037-21,190,231 Size: 48,195 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr19:21,142,184-21,189,891 Size: 47,708 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BX647597 - Homo sapiens mRNA; cDNA DKFZp313E0830 (from clone DKFZp313E0830). AK308127 - Homo sapiens cDNA, FLJ98075. AK293072 - Homo sapiens cDNA FLJ77400 complete cds, highly similar to Homo sapiens zinc finger protein 431 (ZNF431), mRNA. AB075849 - Homo sapiens mRNA for KIAA1969 protein. BC065374 - Homo sapiens cDNA clone IMAGE:6215349, partial cds. BC040506 - Homo sapiens zinc finger protein 431, mRNA (cDNA clone MGC:33940 IMAGE:5297447), complete cds. JD373938 - Sequence 354962 from Patent EP1572962. JD215583 - Sequence 196607 from Patent EP1572962. KJ900390 - Synthetic construct Homo sapiens clone ccsbBroadEn_09784 ZNF431 gene, encodes complete protein. AB384338 - Synthetic construct DNA, clone: pF1KSDA1969, Homo sapiens ZNF431 gene for zinc finger protein 431, complete cds, without stop codon, in Flexi system. JD138214 - Sequence 119238 from Patent EP1572962. JD175725 - Sequence 156749 from Patent EP1572962. JD332015 - Sequence 313039 from Patent EP1572962. JD447677 - Sequence 428701 from Patent EP1572962. JD085108 - Sequence 66132 from Patent EP1572962. JD249563 - Sequence 230587 from Patent EP1572962. JD378009 - Sequence 359033 from Patent EP1572962. JD354048 - Sequence 335072 from Patent EP1572962. JD364619 - Sequence 345643 from Patent EP1572962. JD050853 - Sequence 31877 from Patent EP1572962. JD097448 - Sequence 78472 from Patent EP1572962. JD534436 - Sequence 515460 from Patent EP1572962. JD050854 - Sequence 31878 from Patent EP1572962. JD451543 - Sequence 432567 from Patent EP1572962. JD364620 - Sequence 345644 from Patent EP1572962.