Human Gene ZNF431 (ENST00000594425.5) from GENCODE V44
  Description: zinc finger protein 431 (from HGNC ZNF431)
RefSeq Summary (NR_138053): This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000594425.5
Gencode Gene: ENSG00000196705.8
Transcript (Including UTRs)
   Position: hg38 chr19:21,142,037-21,190,231 Size: 48,195 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr19:21,142,184-21,189,891 Size: 47,708 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:21,142,037-21,190,231)mRNA (may differ from genome)Protein (40 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.20 RPKM in Ovary
Total median expression: 122.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.90147-0.299 Picture PostScript Text
3' UTR -99.30340-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BX647597 - Homo sapiens mRNA; cDNA DKFZp313E0830 (from clone DKFZp313E0830).
AK308127 - Homo sapiens cDNA, FLJ98075.
AK293072 - Homo sapiens cDNA FLJ77400 complete cds, highly similar to Homo sapiens zinc finger protein 431 (ZNF431), mRNA.
AB075849 - Homo sapiens mRNA for KIAA1969 protein.
BC065374 - Homo sapiens cDNA clone IMAGE:6215349, partial cds.
BC040506 - Homo sapiens zinc finger protein 431, mRNA (cDNA clone MGC:33940 IMAGE:5297447), complete cds.
JD373938 - Sequence 354962 from Patent EP1572962.
JD215583 - Sequence 196607 from Patent EP1572962.
KJ900390 - Synthetic construct Homo sapiens clone ccsbBroadEn_09784 ZNF431 gene, encodes complete protein.
AB384338 - Synthetic construct DNA, clone: pF1KSDA1969, Homo sapiens ZNF431 gene for zinc finger protein 431, complete cds, without stop codon, in Flexi system.
JD138214 - Sequence 119238 from Patent EP1572962.
JD175725 - Sequence 156749 from Patent EP1572962.
JD332015 - Sequence 313039 from Patent EP1572962.
JD447677 - Sequence 428701 from Patent EP1572962.
JD085108 - Sequence 66132 from Patent EP1572962.
JD249563 - Sequence 230587 from Patent EP1572962.
JD378009 - Sequence 359033 from Patent EP1572962.
JD354048 - Sequence 335072 from Patent EP1572962.
JD364619 - Sequence 345643 from Patent EP1572962.
JD050853 - Sequence 31877 from Patent EP1572962.
JD097448 - Sequence 78472 from Patent EP1572962.
JD534436 - Sequence 515460 from Patent EP1572962.
JD050854 - Sequence 31878 from Patent EP1572962.
JD451543 - Sequence 432567 from Patent EP1572962.
JD364620 - Sequence 345644 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK308127, ENST00000594425.1, ENST00000594425.2, ENST00000594425.3, ENST00000594425.4, M0QXY3, uc060wgh.1
UCSC ID: ENST00000594425.5
RefSeq Accession: NR_138053

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.