Human Gene SLC11A1 (ENST00000354352.9) from GENCODE V44
Description: solute carrier family 11 member 1 (from HGNC SLC11A1) RefSeq Summary (NM_000578): This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000354352.9 Gencode Gene: ENSG00000018280.17 Transcript (Including UTRs) Position: hg38 chr2:218,382,248-218,395,323 Size: 13,076 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chr2:218,382,369-218,386,659 Size: 4,291 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01566 - Natural resistance-associated macrophage protein
ModBase Predicted Comparative 3D Structure on Q9HBK0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK307954 - Homo sapiens cDNA, FLJ97902. D50402 - Homo sapiens mRNA for NRAMP1, complete cds. AB209650 - Homo sapiens mRNA for solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 variant protein. AK310914 - Homo sapiens cDNA, FLJ17956. AK303398 - Homo sapiens cDNA FLJ54317 complete cds, highly similar to Natural resistance-associated macrophage protein 1. AK298667 - Homo sapiens cDNA FLJ60324 complete cds, highly similar to Natural resistance-associated macrophage protein 1. AK311405 - Homo sapiens cDNA, FLJ18447. D50403 - Homo sapiens mRNA for NRAMP1, complete cds. AK294707 - Homo sapiens cDNA FLJ53784 complete cds, highly similar to Natural resistance-associated macrophage protein 1. BC041787 - Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, mRNA (cDNA clone IMAGE:4717241), with apparent retained intron. L32185 - Homo sapiens integral membrane protein (NRAMP1) mRNA, complete cds. BC071165 - Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, mRNA (cDNA clone MGC:90282 IMAGE:5756382), complete cds. BC033754 - Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, mRNA (cDNA clone IMAGE:5212319). BC037550 - Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, mRNA (cDNA clone IMAGE:5213746), with apparent retained intron. D38171 - Homo sapiens mRNA for Nramp, complete cds. CU687102 - Synthetic construct Homo sapiens gateway clone IMAGE:100022910 5' read SLC11A1 mRNA. KJ904563 - Synthetic construct Homo sapiens clone ccsbBroadEn_13957 SLC11A1 gene, encodes complete protein. JD059600 - Sequence 40624 from Patent EP1572962. JD488059 - Sequence 469083 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04142 - Lysosome