Human Gene DSTN (ENST00000449141.2) from GENCODE V44
Description: Contains 1 ADF-H domain. (from UniProt F6RFD5) RefSeq Summary (NM_006870): The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000449141.2 Gencode Gene: ENSG00000125868.16 Transcript (Including UTRs) Position: hg38 chr20:17,570,090-17,607,222 Size: 37,133 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr20:17,570,209-17,605,129 Size: 34,921 Coding Exon Count: 4
ID:F6RFD5_HUMAN DESCRIPTION: SubName: Full=Destrin; SIMILARITY: Contains 1 ADF-H domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00241 - Cofilin/tropomyosin-type actin-binding protein
ModBase Predicted Comparative 3D Structure on F6RFD5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
