Human Gene CLDN5 (ENST00000618236.2) from GENCODE V44
Description: Homo sapiens claudin 5 (CLDN5), transcript variant 4, mRNA. (from RefSeq NM_001363066) RefSeq Summary (NM_001363066): This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]. Gencode Transcript: ENST00000618236.2 Gencode Gene: ENSG00000184113.10 Transcript (Including UTRs) Position: hg38 chr22:19,523,027-19,524,410 Size: 1,384 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr22:19,523,599-19,524,255 Size: 657 Coding Exon Count: 1
ID:CLD5_HUMAN DESCRIPTION: RecName: Full=Claudin-5; AltName: Full=Transmembrane protein deleted in VCFS; Short=TMDVCF; FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). SUBUNIT: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO- 3. Interacts with MPDZ (By similarity). SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the claudin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00822 - PMP-22/EMP/MP20/Claudin family
ModBase Predicted Comparative 3D Structure on O00501
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
