Human Gene VIPR2 (ENST00000377633.7) from GENCODE V44
Description: Homo sapiens vasoactive intestinal peptide receptor 2 (VIPR2), transcript variant 4, mRNA. (from RefSeq NM_001308259) RefSeq Summary (NM_001308259): This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000377633.7 Gencode Gene: ENSG00000106018.14 Transcript (Including UTRs) Position: hg38 chr7:159,030,455-159,097,204 Size: 66,750 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr7:159,030,616-159,097,143 Size: 66,528 Coding Exon Count: 10
ID:VIPR2_HUMAN DESCRIPTION: RecName: Full=Vasoactive intestinal polypeptide receptor 2; Short=VIP-R-2; AltName: Full=Helodermin-preferring VIP receptor; AltName: Full=Pituitary adenylate cyclase-activating polypeptide type III receptor; Short=PACAP type III receptor; Short=PACAP-R-3; Short=PACAP-R3; AltName: Full=VPAC2; Flags: Precursor; FUNCTION: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in CD4+ T-cells, but not in CD8+ T- cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78. SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41587
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
