Human Gene PTK2B (ENST00000412793.5) from GENCODE V44
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt C9JHV9) RefSeq Summary (NM_173175): This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000412793.5 Gencode Gene: ENSG00000120899.18 Transcript (Including UTRs) Position: hg38 chr8:27,380,651-27,430,388 Size: 49,738 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr8:27,397,585-27,430,388 Size: 32,804 Coding Exon Count: 6
ID:C9JHV9_HUMAN DESCRIPTION: SubName: Full=Protein-tyrosine kinase 2-beta; Flags: Fragment; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on C9JHV9
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004715 non-membrane spanning protein tyrosine kinase activity
Biological Process: GO:0002688 regulation of leukocyte chemotaxis GO:0007165 signal transduction GO:0018108 peptidyl-tyrosine phosphorylation GO:0030155 regulation of cell adhesion GO:0030334 regulation of cell migration GO:0030500 regulation of bone mineralization GO:0042127 regulation of cell proliferation GO:0045765 regulation of angiogenesis GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component: GO:0005856 cytoskeleton GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Descriptions from all associated GenBank mRNAs
S80542 - Homo sapiens related adhesion focal tyrosine kinase (RAFTK) mRNA, complete cds. BC036651 - Homo sapiens PTK2B protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:26516 IMAGE:4824966), complete cds. D45853 - Homo sapiens CAK beta mRNA for cell adhesion kinase beta, partial cds. U43522 - Human cell adhesion kinase beta (CAKbeta) mRNA, complete cds. BC042599 - Homo sapiens PTK2B protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:17184 IMAGE:4343040), complete cds. L49207 - Homo sapiens (clone B6a) focal adhesion kinase (FAK2) mRNA, complete cds. AB209085 - Homo sapiens mRNA for PTK2B protein tyrosine kinase 2 beta isoform a variant protein. U33284 - Human protein tyrosine kinase PYK2 mRNA, complete cds. AB527606 - Synthetic construct DNA, clone: pF1KB8561, Homo sapiens PTK2B gene for PTK2B protein tyrosine kinase 2 beta, without stop codon, in Flexi system.
BioCarta from NCI Cancer Genome Anatomy Project h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage h_pyk2Pathway - Links between Pyk2 and Map Kinases h_metPathway - Signaling of Hepatocyte Growth Factor Receptor h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity h_cxcr4Pathway - CXCR4 Signaling Pathway h_il7Pathway - IL-7 Signal Transduction h_Par1Pathway - Thrombin signaling and protease-activated receptors h_achPathway - Role of nicotinic acetylcholine receptors in the regulation of apoptosis h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_ionPathway - Ion Channel and Phorbal Esters Signaling Pathway
US Server
