Human Gene MRPS28 (ENST00000520946.1) from GENCODE V44
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E5RK86) RefSeq Summary (NM_014018): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000520946.1 Gencode Gene: ENSG00000147586.10 Transcript (Including UTRs) Position: hg38 chr8:79,919,032-80,029,974 Size: 110,943 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr8:79,919,032-80,028,781 Size: 109,750 Coding Exon Count: 3
ID:E5RK86_HUMAN DESCRIPTION: SubName: Full=28S ribosomal protein S28, mitochondrial; Flags: Fragment; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10246 - Mitochondrial ribosomal protein MRP-S35
ModBase Predicted Comparative 3D Structure on E5RK86
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.