Human Gene DLG3 (ENST00000194900.8) from GENCODE V44
Description: Contains 1 SH3 domain. (from UniProt Q5JUW8) RefSeq Summary (NM_021120): This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]. Gencode Transcript: ENST00000194900.8 Gencode Gene: ENSG00000082458.12 Transcript (Including UTRs) Position: hg38 chrX:70,444,861-70,505,490 Size: 60,630 Total Exon Count: 21 Strand: + Coding Region Position: hg38 chrX:70,445,202-70,502,269 Size: 57,068 Coding Exon Count: 21
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00625 - Guanylate kinase PF10608 - Polyubiquitination (PEST) N-terminal domain of MAGUK PF00595 - PDZ domain (Also known as DHR or GLGF) PF10600 - PDZ-associated domain of NMDA receptors PF00018 - SH3 domain
ModBase Predicted Comparative 3D Structure on Q5JUW8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
