Human Gene NRK (ENST00000243300.14) from GENCODE V44
Description: Homo sapiens Nik related kinase (NRK), mRNA. (from RefSeq NM_198465) RefSeq Summary (NM_198465): The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000243300.14 Gencode Gene: ENSG00000123572.17 Transcript (Including UTRs) Position: hg38 chrX:105,822,539-105,958,610 Size: 136,072 Total Exon Count: 29 Strand: + Coding Region Position: hg38 chrX:105,822,846-105,955,600 Size: 132,755 Coding Exon Count: 29
ID:NRK_HUMAN DESCRIPTION: RecName: Full=Nik-related protein kinase; EC=2.7.11.1; FUNCTION: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 CNH domain. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z2Y5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.