Human Gene NRK (ENST00000243300.14) from GENCODE V44
  Description: Homo sapiens Nik related kinase (NRK), mRNA. (from RefSeq NM_198465)
RefSeq Summary (NM_198465): The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010].
Gencode Transcript: ENST00000243300.14
Gencode Gene: ENSG00000123572.17
Transcript (Including UTRs)
   Position: hg38 chrX:105,822,539-105,958,610 Size: 136,072 Total Exon Count: 29 Strand: +
Coding Region
   Position: hg38 chrX:105,822,846-105,955,600 Size: 132,755 Coding Exon Count: 29 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:105,822,539-105,958,610)mRNA (may differ from genome)Protein (1582 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NRK_HUMAN
DESCRIPTION: RecName: Full=Nik-related protein kinase; EC=2.7.11.1;
FUNCTION: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
SIMILARITY: Contains 1 CNH domain.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NRK
Diseases sorted by gene-association score: hypermobility syndrome (6), sotos syndrome 1 (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.84 RPKM in Ovary
Total median expression: 47.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.00307-0.124 Picture PostScript Text
3' UTR -651.403010-0.216 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001180 - Citron
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00780 - CNH domain
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on Q7Z2Y5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0007256 activation of JNKK activity
GO:0007346 regulation of mitotic cell cycle
GO:0007567 parturition
GO:0008285 negative regulation of cell proliferation
GO:0016310 phosphorylation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0042981 regulation of apoptotic process
GO:0048812 neuron projection morphogenesis
GO:0060721 regulation of spongiotrophoblast cell proliferation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BX538345 - Homo sapiens mRNA; cDNA DKFZp686A17109 (from clone DKFZp686A17109); complete cds.
AK131549 - Homo sapiens cDNA FLJ16788 fis, clone PLACE7013963, weakly similar to Mus musculus Nik related kinase (Nrk).
AM392900 - Synthetic construct Homo sapiens clone IMAGE:100002333 for hypothetical protein (NRK gene).
AM393343 - Synthetic construct Homo sapiens clone IMAGE:100002360 for hypothetical protein (NRK gene).
BC172241 - Synthetic construct Homo sapiens clone IMAGE:100068935, MGC:198946 Nik related kinase (NRK) mRNA, encodes complete protein.
BC172556 - Synthetic construct Homo sapiens clone IMAGE:100069250, MGC:199261 Nik related kinase (NRK) mRNA, encodes complete protein.
BC108702 - Homo sapiens Nik related kinase, mRNA (cDNA clone IMAGE:5722833), complete cds.
JD248944 - Sequence 229968 from Patent EP1572962.
JD350879 - Sequence 331903 from Patent EP1572962.
JD334913 - Sequence 315937 from Patent EP1572962.
AK300377 - Homo sapiens cDNA FLJ55423 complete cds, highly similar to Homo sapiens Nik related kinase (NRK), mRNA.
AK293500 - Homo sapiens cDNA FLJ50079 complete cds, highly similar to Homo sapiens Nik related kinase (NRK), mRNA.
JD241781 - Sequence 222805 from Patent EP1572962.
JD563333 - Sequence 544357 from Patent EP1572962.
JD242293 - Sequence 223317 from Patent EP1572962.
JD037632 - Sequence 18656 from Patent EP1572962.
JD327744 - Sequence 308768 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000243300.1, ENST00000243300.10, ENST00000243300.11, ENST00000243300.12, ENST00000243300.13, ENST00000243300.2, ENST00000243300.3, ENST00000243300.4, ENST00000243300.5, ENST00000243300.6, ENST00000243300.7, ENST00000243300.8, ENST00000243300.9, NM_198465, NRK_HUMAN, Q32ND6, Q5H9K2, Q6ZMP2, Q7Z2Y5, uc065ans.1, uc065ans.2
UCSC ID: ENST00000243300.14
RefSeq Accession: NM_198465
Protein: Q7Z2Y5 (aka NRK_HUMAN)
CCDS: CCDS65305.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.