Human Gene ARHGAP4 (ENST00000393721.5) from GENCODE V44
Description: Contains 1 SH3 domain. (from UniProt E9PCM6) RefSeq Summary (NM_001666): This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. Gencode Transcript: ENST00000393721.5 Gencode Gene: ENSG00000089820.17 Transcript (Including UTRs) Position: hg38 chrX:153,907,367-153,926,254 Size: 18,888 Total Exon Count: 19 Strand: - Coding Region Position: hg38 chrX:153,907,729-153,926,202 Size: 18,474 Coding Exon Count: 19
ID:E9PCM6_HUMAN DESCRIPTION: SubName: Full=Rho GTPase-activating protein 4; SIMILARITY: Contains 1 SH3 domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on E9PCM6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.