C. elegans Gene unc-52 (ZC101.2b)
  Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle.
Transcript (Including UTRs)
   Position: ce6 chrII:14,661,174-14,666,846 Size: 5,673 Total Exon Count: 10 Strand: -
Coding Region
   Position: ce6 chrII:14,661,549-14,666,755 Size: 5,207 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2008-06-03

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding

Biological Process:
GO:0002119 nematode larval development
GO:0007005 mitochondrion organization
GO:0007517 muscle organ development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009792 embryo development ending in birth or egg hatching
GO:0016477 cell migration
GO:0030239 myofibril assembly
GO:0031581 hemidesmosome assembly
GO:0040011 locomotion
GO:0040017 positive regulation of locomotion
GO:0046716 muscle cell cellular homeostasis
GO:0048644 muscle organ morphogenesis
GO:0060279 positive regulation of ovulation
GO:0060298 positive regulation of sarcomere organization
GO:0060465 pharynx development

Cellular Component:
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
GO:0031430 M band
GO:0055120 striated muscle dense body


-  Other Names for This Gene
  WormBase ID: ZC101.2b
RefSeq Accession: NM_064646
Protein: Q06561 (aka UNC52_CAEEL or UN52_CAEEL)

+  WormBase Genes Methods, Credits, and Data Use Restrictions
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