Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle. Transcript (Including UTRs) Position: ce6 chrII:14,661,174-14,666,846 Size: 5,673 Total Exon Count: 10 Strand: - Coding Region Position: ce6 chrII:14,661,549-14,666,755 Size: 5,207 Coding Exon Count: 10
Pfam Domains: PF07679 - Immunoglobulin I-set domain PF00052 - Laminin B (Domain IV) PF00053 - Laminin EGF domain PF02210 - Laminin G domain PF00057 - Low-density lipoprotein receptor domain class A
ModBase Predicted Comparative 3D Structure on Q06561
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary