C. elegans Gene unc-52 (ZC101.2b)
  Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle.
Transcript (Including UTRs)
   Position: ce6 chrII:14,661,174-14,666,846 Size: 5,673 Total Exon Count: 10 Strand: -
Coding Region
   Position: ce6 chrII:14,661,549-14,666,755 Size: 5,207 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2008-06-03

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrII:14,661,174-14,666,846)mRNAProtein (1160 aa)
Gene SorterGenome BrowserOther Species FASTAPubMedRefSeqUniProtKB

+  Comments and Description Text from UniProtKB
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR002049 - EGF_laminin
IPR009030 - Growth_fac_rcpt
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR018031 - Laminin_B_subgr
IPR000034 - Laminin_B_type_IV
IPR001791 - Laminin_G
IPR023415 - LDLR_class-A_CS
IPR002172 - LDrepeatLR_classA_rpt

Pfam Domains:
PF07679 - Immunoglobulin I-set domain
PF00052 - Laminin B (Domain IV)
PF00053 - Laminin EGF domain
PF02210 - Laminin G domain
PF00057 - Low-density lipoprotein receptor domain class A

ModBase Predicted Comparative 3D Structure on Q06561
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding

Biological Process:
GO:0002119 nematode larval development
GO:0007005 mitochondrion organization
GO:0007517 muscle organ development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009792 embryo development ending in birth or egg hatching
GO:0016477 cell migration
GO:0030239 myofibril assembly
GO:0031581 hemidesmosome assembly
GO:0040011 locomotion
GO:0040017 positive regulation of locomotion
GO:0046716 muscle cell cellular homeostasis
GO:0048644 muscle organ morphogenesis
GO:0060279 positive regulation of ovulation
GO:0060298 positive regulation of sarcomere organization
GO:0060465 pharynx development

Cellular Component:
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
GO:0031430 M band
GO:0055120 striated muscle dense body

-  Other Names for This Gene
  WormBase ID: ZC101.2b
RefSeq Accession: NM_064646
Protein: Q06561 (aka UNC52_CAEEL or UN52_CAEEL)

-  WormBase Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.