Human Gene TMEM132A (uc001nqi.1)
  Description: transmembrane protein 132A isoform a
RefSeq Summary (NM_017870): This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg18 chr11:60,448,489-60,461,207 Size: 12,719 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg18 chr11:60,448,682-60,460,955 Size: 12,274 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:60,448,489-60,461,207)mRNA (may differ from genome)Protein (1024 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDMGIOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -102.50193-0.531 Picture PostScript Text
3' UTR -84.00252-0.333 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q24JP5-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  BC028106 - Homo sapiens transmembrane protein 132A, mRNA (cDNA clone IMAGE:5247458), partial cds.
AK000546 - Homo sapiens cDNA FLJ20539 fis, clone KAT11311.
BC114569 - Homo sapiens transmembrane protein 132A, transcript variant 2, mRNA (cDNA clone MGC:138669 IMAGE:40036200), complete cds.
BC032059 - Homo sapiens transmembrane protein 132A, mRNA (cDNA clone IMAGE:5173525), partial cds.
AL834133 - Homo sapiens mRNA; cDNA DKFZp547K1515 (from clone DKFZp547K1515).
AB046803 - Homo sapiens mRNA for KIAA1583 protein, partial cds.
AL359557 - Homo sapiens mRNA; cDNA DKFZp547E212 (from clone DKFZp547E212).
AK023577 - Homo sapiens cDNA FLJ13515 fis, clone PLACE1005595.
JC737773 - Sequence 29 from Patent WO2014075939.
JC737778 - Sequence 34 from Patent WO2014075939.
JC737786 - Sequence 42 from Patent WO2014075939.
JC737800 - Sequence 56 from Patent WO2014075939.
JC506661 - Sequence 29 from Patent EP2733220.
JC506666 - Sequence 34 from Patent EP2733220.
JC506674 - Sequence 42 from Patent EP2733220.
JC506688 - Sequence 56 from Patent EP2733220.
JD426193 - Sequence 407217 from Patent EP1572962.
JD362594 - Sequence 343618 from Patent EP1572962.
JD389527 - Sequence 370551 from Patent EP1572962.
JD407340 - Sequence 388364 from Patent EP1572962.
JD483857 - Sequence 464881 from Patent EP1572962.
JD484329 - Sequence 465353 from Patent EP1572962.
JD482764 - Sequence 463788 from Patent EP1572962.
JD421159 - Sequence 402183 from Patent EP1572962.
KJ894107 - Synthetic construct Homo sapiens clone ccsbBroadEn_03501 TMEM132A gene, encodes complete protein.
JD215086 - Sequence 196110 from Patent EP1572962.
JD270999 - Sequence 252023 from Patent EP1572962.
LF211254 - JP 2014500723-A/18757: Polycomb-Associated Non-Coding RNAs.
LF211253 - JP 2014500723-A/18756: Polycomb-Associated Non-Coding RNAs.
LF345060 - JP 2014500723-A/152563: Polycomb-Associated Non-Coding RNAs.
LF345059 - JP 2014500723-A/152562: Polycomb-Associated Non-Coding RNAs.
LF345058 - JP 2014500723-A/152561: Polycomb-Associated Non-Coding RNAs.
LF345057 - JP 2014500723-A/152560: Polycomb-Associated Non-Coding RNAs.
LF345056 - JP 2014500723-A/152559: Polycomb-Associated Non-Coding RNAs.
MA580637 - JP 2018138019-A/152563: Polycomb-Associated Non-Coding RNAs.
MA580636 - JP 2018138019-A/152562: Polycomb-Associated Non-Coding RNAs.
MA580635 - JP 2018138019-A/152561: Polycomb-Associated Non-Coding RNAs.
MA580634 - JP 2018138019-A/152560: Polycomb-Associated Non-Coding RNAs.
MA580633 - JP 2018138019-A/152559: Polycomb-Associated Non-Coding RNAs.
MA446831 - JP 2018138019-A/18757: Polycomb-Associated Non-Coding RNAs.
MA446830 - JP 2018138019-A/18756: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q24JP5 (Reactome details) participates in the following event(s):

R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification

-  Other Names for This Gene
  Alternate Gene Symbols: HSPA5BP1, KIAA1583, NM_017870, NP_060340, Q24JP5-2
UCSC ID: uc001nqi.1
RefSeq Accession: NM_017870
Protein: Q24JP5-2, splice isoform of Q24JP5 CCDS: CCDS7997.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_017870.3
exon count: 11CDS single in 3' UTR: no RNA size: 3520
ORF size: 3075CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6311.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.