Description: SON DNA-binding protein isoform F RefSeq Summary (NM_138927): This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg18 chr21:33,837,220-33,871,682 Size: 34,463 Total Exon Count: 12 Strand: + Coding Region Position: hg18 chr21:33,837,269-33,870,600 Size: 33,332 Coding Exon Count: 12
ID:SON_HUMAN DESCRIPTION: RecName: Full=Protein SON; AltName: Full=Bax antagonist selected in saccharomyces 1; Short=BASS1; AltName: Full=Negative regulatory element-binding protein; Short=NRE-binding protein; AltName: Full=Protein DBP-5; AltName: Full=SON3; FUNCTION: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that posses weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that posses weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. SUBUNIT: Interacts with SRSF2. Associates with the spliceosome. Interacts with the AML1-MTG8 (AML1-ETO) fusion protein, possibly leading to trigger signals inhibiting leukemogenesis. SUBCELLULAR LOCATION: Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2. TISSUE SPECIFICITY: Widely expressed, with the higher expression seen in leukocyte and heart. DOMAIN: Contains 8 types of repeats which are distributed in 3 regions. SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain. SIMILARITY: Contains 1 G-patch domain. SEQUENCE CAUTION: Sequence=AAH02422.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA82971.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA44793.1; Type=Frameshift; Positions=2315, 2412, 2417; Sequence=CAC69885.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18583
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
JC737888 - Sequence 144 from Patent WO2014075939. JC738095 - Sequence 351 from Patent WO2014075939. BC029455 - Homo sapiens SON DNA binding protein, mRNA (cDNA clone IMAGE:4075982), partial cds. AK307612 - Homo sapiens cDNA, FLJ97560. BC104656 - Homo sapiens SON DNA binding protein, mRNA (cDNA clone IMAGE:6739312), partial cds. AY026895 - Homo sapiens NREBP mRNA, complete cds. AK127947 - Homo sapiens cDNA FLJ46057 fis, clone T1ESE2000609, highly similar to SON protein. AK024752 - Homo sapiens cDNA: FLJ21099 fis, clone CAS04610. BC005337 - Homo sapiens SON DNA binding protein, mRNA (cDNA clone IMAGE:3998051), partial cds. AF161428 - Homo sapiens HSPC310 mRNA, partial cds. AF380180 - Homo sapiens SON DNA binding protein isoform B (SON) mRNA, complete cds, alternatively spliced. AF380179 - Homo sapiens SON DNA binding protein isoform A (SON) mRNA, complete cds, alternatively spliced. AF380181 - Homo sapiens SON DNA binding protein isoform C (SON) mRNA, complete cds, alternatively spliced. AF380183 - Homo sapiens SON DNA binding protein isoform E (SON) mRNA, complete cds, alternatively spliced. AF380184 - Homo sapiens SON DNA binding protein isoform F (SON) mRNA, complete cds, alternatively spliced. AF161430 - Homo sapiens HSPC312 mRNA, partial cds. AB028942 - Homo sapiens KIAA1019 mRNA for KIAA1019 protein. BC066303 - Homo sapiens SON DNA binding protein, mRNA (cDNA clone IMAGE:4793409). BC046101 - Homo sapiens SON DNA binding protein, mRNA (cDNA clone IMAGE:5552607), containing frame-shift errors. AF435977 - Homo sapiens negative regulatory element-binding protein (SON) mRNA, complete cds, alternatively spliced. BC054029 - Homo sapiens SON DNA binding protein, mRNA (cDNA clone IMAGE:5185870). AK091233 - Homo sapiens cDNA FLJ33914 fis, clone CTONG2016575, highly similar to SON PROTEIN. AX746865 - Sequence 390 from Patent EP1308459. AK074269 - Homo sapiens cDNA FLJ23689 fis, clone HEP10174, highly similar to SON PROTEIN. AK128071 - Homo sapiens cDNA FLJ46192 fis, clone TESTI4005653, moderately similar to Homo sapiens SON DNA binding protein (SON). BC002422 - Homo sapiens SON DNA binding protein, mRNA (cDNA clone IMAGE:3161999), partial cds. X63753 - Homo sapiens son-a mRNA. X63751 - Homo sapiens mRNA for putative DNA binding protein (son-b). X63071 - H.sapiens mRNA for novel DNA binding protein. BC017278 - Homo sapiens cDNA clone IMAGE:4853468, partial cds. AF139897 - Homo sapiens BASS1 (BASS1) mRNA, partial cds. AF380182 - Homo sapiens SON DNA binding protein isoform D (SON) mRNA, complete cds, alternatively spliced. JC515159 - Sequence 5412 from Patent WO2014113089. JC506776 - Sequence 144 from Patent EP2733220. JC506983 - Sequence 351 from Patent EP2733220. JC515158 - Sequence 5411 from Patent WO2014113089. JD535242 - Sequence 516266 from Patent EP1572962. JD377491 - Sequence 358515 from Patent EP1572962. JD348624 - Sequence 329648 from Patent EP1572962. JD557759 - Sequence 538783 from Patent EP1572962. JD502446 - Sequence 483470 from Patent EP1572962. JD503410 - Sequence 484434 from Patent EP1572962. JD385345 - Sequence 366369 from Patent EP1572962. JD310635 - Sequence 291659 from Patent EP1572962. JD278510 - Sequence 259534 from Patent EP1572962. JD130157 - Sequence 111181 from Patent EP1572962. JD297016 - Sequence 278040 from Patent EP1572962. JD108762 - Sequence 89786 from Patent EP1572962. JD225016 - Sequence 206040 from Patent EP1572962. HZ482496 - JP 2015535430-A/3002: TERMINALLY MODIFIED RNA. HZ482495 - JP 2015535430-A/3001: TERMINALLY MODIFIED RNA. LP715493 - Sequence 14 from Patent WO2016001030. LQ072747 - Sequence 3071 from Patent EP2964234. LQ072746 - Sequence 3070 from Patent EP2964234. HZ792427 - JP 2016504050-A/4172: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. HZ792426 - JP 2016504050-A/4171: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. LF160540 - JP 2016513950-A/606: Oligomers with improved off-target profile. LF161491 - JP 2016513950-A/1557: Oligomers with improved off-target profile. LF210669 - JP 2014500723-A/18172: Polycomb-Associated Non-Coding RNAs. LF339913 - JP 2014500723-A/147416: Polycomb-Associated Non-Coding RNAs. MS947304 - Sequence 20 from Patent WO2017037057. MS947353 - Sequence 69 from Patent WO2017037057. MA405685 - WO 2018155427-A/459: A probe with reduced false positive binding, a method to desing the probe, and the use thereof. MA446246 - JP 2018138019-A/18172: Polycomb-Associated Non-Coding RNAs. MA575490 - JP 2018138019-A/147416: Polycomb-Associated Non-Coding RNAs. MA646248 - JP 2017113010-A/4172: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA734132 - JP 2017140048-A/3002: TERMINALLY MODIFIED RNA. MA646247 - JP 2017113010-A/4171: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA734131 - JP 2017140048-A/3001: TERMINALLY MODIFIED RNA. MP015024 - Sequence 227 from Patent WO2019016252. MA803301 - JP 2018183181-A/4172: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA803300 - JP 2018183181-A/4171: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
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