Description: bladder cancer associated protein RefSeq Summary (NM_006698): This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]. Transcript (Including UTRs) Position: hg18 chr20:35,579,233-35,589,717 Size: 10,485 Total Exon Count: 2 Strand: - Coding Region Position: hg18 chr20:35,580,727-35,580,990 Size: 264 Coding Exon Count: 1
ID:BLCAP_HUMAN DESCRIPTION: RecName: Full=Bladder cancer-associated protein; AltName: Full=Bladder cancer 10 kDa protein; Short=Bc10; FUNCTION: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. INTERACTION: P03372:ESR1; NbExp=2; IntAct=EBI-3895726, EBI-78473; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in cervical tissues. Down-regulated during bladder cancer progression and in most cervical carcinomas. SIMILARITY: Belongs to the BLCAP family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BLCAPID801ch20q11.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06726 - Bladder cancer-related protein BC10
ModBase Predicted Comparative 3D Structure on P62952
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
