Description: eukaryotic translation initiation factor 2 beta RefSeq Summary (NM_003908): Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]. Transcript (Including UTRs) Position: hg18 chr20:32,139,776-32,163,746 Size: 23,971 Total Exon Count: 9 Strand: - Coding Region Position: hg18 chr20:32,141,197-32,163,577 Size: 22,381 Coding Exon Count: 9
ID:IF2B_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 2 subunit 2; AltName: Full=Eukaryotic translation initiation factor 2 subunit beta; Short=eIF-2-beta; FUNCTION: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). INTERACTION: P05198:EIF2S1; NbExp=5; IntAct=EBI-711977, EBI-1056162; P41091:EIF2S3; NbExp=3; IntAct=EBI-711977, EBI-1054228; SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20042
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_eif2Pathway - Regulation of eIF2 h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway h_rnaPathway - Double Stranded RNA Induced Gene Expression
Reactome (by CSHL, EBI, and GO)
Protein P20042 (Reactome details) participates in the following event(s):
R-HSA-72663 De novo formation of eIF2:GTP R-HSA-72697 Start codon recognition R-HSA-5227009 ABCF1 binds EIF2 R-HSA-72722 eIF2 activation R-HSA-72670 Formation of eIF2:GDP:eIF2B intermediate R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72669 Met-tRNAi binds to eIF2:GTP to form the ternary complex R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72621 Ribosomal scanning R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-382556 ABC-family proteins mediated transport R-HSA-72731 Recycling of eIF2:GDP R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72737 Cap-dependent Translation Initiation R-HSA-382551 Transport of small molecules R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72649 Translation initiation complex formation R-HSA-72766 Translation R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
