Human Gene KRTAP1-5 (uc002kgs.1)
  Description: keratin associated protein 1.5
RefSeq Summary (NM_031957): This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg18 chr17_random:326,123-327,298 Size: 1,176 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg18 chr17_random:326,170-326,694 Size: 525 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17_random:326,123-327,298)mRNA (may differ from genome)Protein (174 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KRA15_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 1-5; AltName: Full=High sulfur keratin-associated protein 1.5; AltName: Full=Keratin-associated protein 1.5;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
SUBUNIT: Interacts with hair keratins.
TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
SIMILARITY: Belongs to the KRTAP type 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.3547-0.029 Picture PostScript Text
3' UTR -132.79604-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002494 - Keratin-assoc

Pfam Domains:
PF01500 - Keratin, high sulfur B2 protein

ModBase Predicted Comparative 3D Structure on Q9BYS1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process
GO:0031424 keratinization

Cellular Component:
GO:0005575 cellular_component
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0045095 keratin filament


-  Descriptions from all associated GenBank mRNAs
  BC101555 - Homo sapiens keratin associated protein 1-5, mRNA (cDNA clone MGC:126604 IMAGE:8069061), complete cds.
BC093841 - Homo sapiens keratin associated protein 1-5, mRNA (cDNA clone MGC:120876 IMAGE:7939686), complete cds.
BC069533 - Homo sapiens keratin associated protein 1-5, mRNA (cDNA clone MGC:96962 IMAGE:7262171), complete cds.
AJ406928 - Homo sapiens mRNA for keratin associated protein 1.5 (KRTAP1.5 gene).
JD549695 - Sequence 530719 from Patent EP1572962.
JD500019 - Sequence 481043 from Patent EP1572962.
JD362675 - Sequence 343699 from Patent EP1572962.
JD530309 - Sequence 511333 from Patent EP1572962.
JD435263 - Sequence 416287 from Patent EP1572962.
KJ904906 - Synthetic construct Homo sapiens clone ccsbBroadEn_14300 KRTAP1-5-like gene, encodes complete protein.
JD168331 - Sequence 149355 from Patent EP1572962.
JD166513 - Sequence 147537 from Patent EP1572962.
LP896071 - Sequence 935 from Patent EP3253886.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BYS1 (Reactome details) participates in the following event(s):

R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: KAP1.5, KRA15_HUMAN, KRTAP1.5, NM_031957, NP_114163, Q52LP6, Q9BYS1
UCSC ID: uc002kgs.1
RefSeq Accession: NM_031957
Protein: Q9BYS1 (aka KRA15_HUMAN or KR15_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_031957.1
exon count: 1CDS single in 3' UTR: no RNA size: 1193
ORF size: 525CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 923.00frame shift in genome: no % Coverage: 98.58
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.