Human Gene KRTAP1-5 (uc002kgs.1)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: KRA15_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 1-5; AltName: Full=High sulfur keratin-associated protein 1.5; AltName: Full=Keratin-associated protein 1.5;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. SUBUNIT: Interacts with hair keratins. TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. SIMILARITY: Belongs to the KRTAP type 1 family.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR002494 - Keratin-assoc
Pfam Domains: PF01500 - Keratin, high sulfur B2 protein
ModBase Predicted Comparative 3D Structure on Q9BYS1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC101555 - Homo sapiens keratin associated protein 1-5, mRNA (cDNA clone MGC:126604 IMAGE:8069061), complete cds. BC093841 - Homo sapiens keratin associated protein 1-5, mRNA (cDNA clone MGC:120876 IMAGE:7939686), complete cds. BC069533 - Homo sapiens keratin associated protein 1-5, mRNA (cDNA clone MGC:96962 IMAGE:7262171), complete cds. AJ406928 - Homo sapiens mRNA for keratin associated protein 1.5 (KRTAP1.5 gene). JD549695 - Sequence 530719 from Patent EP1572962. JD500019 - Sequence 481043 from Patent EP1572962. JD362675 - Sequence 343699 from Patent EP1572962. JD530309 - Sequence 511333 from Patent EP1572962. JD435263 - Sequence 416287 from Patent EP1572962. KJ904906 - Synthetic construct Homo sapiens clone ccsbBroadEn_14300 KRTAP1-5-like gene, encodes complete protein. JD168331 - Sequence 149355 from Patent EP1572962. JD166513 - Sequence 147537 from Patent EP1572962. LP896071 - Sequence 935 from Patent EP3253886.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: KAP1.5, KRA15_HUMAN, KRTAP1.5, NM_031957, NP_114163, Q52LP6, Q9BYS1 UCSC ID: uc002kgs.1 RefSeq Accession: NM_031957
Protein: Q9BYS1
(aka KRA15_HUMAN or KR15_HUMAN)
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Gene Model Information
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category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_031957.1
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exon count:
| 1 | CDS single in 3' UTR:
| no
| RNA size:
| 1193 |
ORF size:
| 525 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 923.00 | frame shift in genome:
| no
| % Coverage:
| 98.58 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 2 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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