Description: coiled-coil domain containing 49 RefSeq Summary (NM_017748): This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]. Transcript (Including UTRs) Position: hg18 chr17:34,210,972-34,235,115 Size: 24,144 Total Exon Count: 10 Strand: - Coding Region Position: hg18 chr17:34,211,871-34,234,962 Size: 23,092 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NXE8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
CR749362 - Homo sapiens mRNA; cDNA DKFZp779M0968 (from clone DKFZp779M0968). AK225373 - Homo sapiens mRNA for hypothetical protein LOC54883 variant, clone: HRC01426. BC008833 - Homo sapiens coiled-coil domain containing 49, mRNA (cDNA clone MGC:12612 IMAGE:4304656), complete cds. AK000298 - Homo sapiens cDNA FLJ20291 fis, clone HEP04788. AK296115 - Homo sapiens cDNA FLJ52308 complete cds. AB587360 - Synthetic construct DNA, clone: pF1KB0960, Homo sapiens CCDC49 gene for coiled-coil domain containing 49, without stop codon, in Flexi system. AK316077 - Homo sapiens cDNA, FLJ78976 complete cds. AK302983 - Homo sapiens cDNA FLJ55385 complete cds. BC003085 - Homo sapiens coiled-coil domain containing 49, mRNA (cDNA clone IMAGE:3358029), partial cds. JD362142 - Sequence 343166 from Patent EP1572962. JD424496 - Sequence 405520 from Patent EP1572962. JD530001 - Sequence 511025 from Patent EP1572962. JD494832 - Sequence 475856 from Patent EP1572962. JD091646 - Sequence 72670 from Patent EP1572962. JD244818 - Sequence 225842 from Patent EP1572962. JD302635 - Sequence 283659 from Patent EP1572962. JD196221 - Sequence 177245 from Patent EP1572962. JD083117 - Sequence 64141 from Patent EP1572962. JD044078 - Sequence 25102 from Patent EP1572962. JD235353 - Sequence 216377 from Patent EP1572962. JD174369 - Sequence 155393 from Patent EP1572962. JD265332 - Sequence 246356 from Patent EP1572962. JD225176 - Sequence 206200 from Patent EP1572962. JD263477 - Sequence 244501 from Patent EP1572962. JD141328 - Sequence 122352 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NXE8 (Reactome details) participates in the following event(s):
R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA