ID:DIEXF_HUMAN DESCRIPTION: RecName: Full=Digestive organ expansion factor homolog; FUNCTION: Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus, nucleolus. SIMILARITY: Belongs to the def family. SEQUENCE CAUTION: Sequence=CAI95693.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06862 - Protein of unknown function (DUF1253)
ModBase Predicted Comparative 3D Structure on Q68CQ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK314061 - Homo sapiens cDNA, FLJ94727. AK289613 - Homo sapiens cDNA FLJ78223 complete cds. BC022964 - Homo sapiens chromosome 1 open reading frame 107, mRNA (cDNA clone MGC:29875 IMAGE:5110673), complete cds. CR749825 - Homo sapiens mRNA; cDNA DKFZp686E19106 (from clone DKFZp686E19106). BX648514 - Homo sapiens mRNA; cDNA DKFZp686L2372 (from clone DKFZp686L2372). CU692760 - Synthetic construct Homo sapiens gateway clone IMAGE:100017804 5' read C1orf107 mRNA. AK096118 - Homo sapiens cDNA FLJ38799 fis, clone LIVER2005198. AK123674 - Homo sapiens cDNA FLJ41680 fis, clone HCASM2003237. AK295799 - Homo sapiens cDNA FLJ52627 complete cds. AK022766 - Homo sapiens cDNA FLJ12704 fis, clone NT2RP1000836. JD527080 - Sequence 508104 from Patent EP1572962. JD402310 - Sequence 383334 from Patent EP1572962. JD566530 - Sequence 547554 from Patent EP1572962. JD361849 - Sequence 342873 from Patent EP1572962. JD506793 - Sequence 487817 from Patent EP1572962. JD505566 - Sequence 486590 from Patent EP1572962. JD399512 - Sequence 380536 from Patent EP1572962. JD420446 - Sequence 401470 from Patent EP1572962. JD563957 - Sequence 544981 from Patent EP1572962. JD451606 - Sequence 432630 from Patent EP1572962. JD433015 - Sequence 414039 from Patent EP1572962. JD435119 - Sequence 416143 from Patent EP1572962. KJ898654 - Synthetic construct Homo sapiens clone ccsbBroadEn_08048 DIEXF gene, encodes complete protein. JD322332 - Sequence 303356 from Patent EP1572962. JD060381 - Sequence 41405 from Patent EP1572962. JD083561 - Sequence 64585 from Patent EP1572962. JD235957 - Sequence 216981 from Patent EP1572962. JD286271 - Sequence 267295 from Patent EP1572962. JD301043 - Sequence 282067 from Patent EP1572962. JD039601 - Sequence 20625 from Patent EP1572962. JD275470 - Sequence 256494 from Patent EP1572962. JD071991 - Sequence 53015 from Patent EP1572962. JD141102 - Sequence 122126 from Patent EP1572962. JD254049 - Sequence 235073 from Patent EP1572962. JD116681 - Sequence 97705 from Patent EP1572962. JD059786 - Sequence 40810 from Patent EP1572962. JD188190 - Sequence 169214 from Patent EP1572962. JD331445 - Sequence 312469 from Patent EP1572962. JD122334 - Sequence 103358 from Patent EP1572962. JD066292 - Sequence 47316 from Patent EP1572962. JD215006 - Sequence 196030 from Patent EP1572962. JD303317 - Sequence 284341 from Patent EP1572962. JD252979 - Sequence 234003 from Patent EP1572962. JD066027 - Sequence 47051 from Patent EP1572962. JD102568 - Sequence 83592 from Patent EP1572962. JD174214 - Sequence 155238 from Patent EP1572962. JD037889 - Sequence 18913 from Patent EP1572962. JD214329 - Sequence 195353 from Patent EP1572962. JD203170 - Sequence 184194 from Patent EP1572962. JD050192 - Sequence 31216 from Patent EP1572962. JD174957 - Sequence 155981 from Patent EP1572962. JD338283 - Sequence 319307 from Patent EP1572962. JD048254 - Sequence 29278 from Patent EP1572962. JD132345 - Sequence 113369 from Patent EP1572962. JD237333 - Sequence 218357 from Patent EP1572962. JD164624 - Sequence 145648 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q68CQ4 (Reactome details) participates in the following event(s):
R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA