Description: phosphatidylinositol 4-kinase type 2 alpha RefSeq Summary (NM_018425): Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg18 chr10:99,390,433-99,426,177 Size: 35,745 Total Exon Count: 9 Strand: + Coding Region Position: hg18 chr10:99,390,490-99,423,489 Size: 33,000 Coding Exon Count: 9
ID:P4K2A_HUMAN DESCRIPTION: RecName: Full=Phosphatidylinositol 4-kinase type 2-alpha; EC=2.7.1.67; AltName: Full=Phosphatidylinositol 4-kinase type II-alpha; FUNCTION: Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. SUBUNIT: Associates with the BLOC-1 and the AP-3 complexes; the BLOC-1 complex is required for optimal binding of PI4K2A to the AP-3 complex. Interacts with BLOC1S5 and DTNBP1. SUBCELLULAR LOCATION: Cytoplasm. Membrane (By similarity). Membrane raft. Cell projection, dendrite (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, synaptosome (By similarity). Mitochondrion (By similarity). Endosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP- 3-complexes-dependent manner. Enriched in neurite tips and neuron projections in a BLOC-1- and AP-3-complexes-dependent manner (By similarity). Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. TISSUE SPECIFICITY: Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. SIMILARITY: Contains 1 PI3K/PI4K domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BTU6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK293733 - Homo sapiens cDNA FLJ56960 complete cds, highly similar to Homo sapiens phosphatidylinositol 4-kinase type II (PI4KII), mRNA. AJ303098 - Homo sapiens mRNA for type II alpha phosphatidylinositol 4-kinase gene. BC003167 - Homo sapiens phosphatidylinositol 4-kinase type 2 alpha, mRNA (cDNA clone MGC:4395 IMAGE:2905670), complete cds. DQ893758 - Synthetic construct Homo sapiens clone IMAGE:100008218; FLH164270.01L; RZPDo839E07161D phosphatidylinositol 4-kinase type II (PI4KII) gene, encodes complete protein. DQ893537 - Synthetic construct clone IMAGE:100006167; FLH164274.01X; RZPDo839E07162D phosphatidylinositol 4-kinase type II (PI4KII) gene, encodes complete protein. BT007330 - Homo sapiens phosphatidylinositol 4-kinase type II mRNA, complete cds. AK309343 - Homo sapiens cDNA, FLJ99384. AL353952 - Homo sapiens mRNA; cDNA DKFZp761G1923 (from clone DKFZp761G1923). AK024317 - Homo sapiens cDNA FLJ14255 fis, clone OVARC1001873. AK023236 - Homo sapiens cDNA FLJ13174 fis, clone NT2RP3003833. AF070611 - Homo sapiens clones 24718 and 24825 mRNA sequence. DL492214 - Novel nucleic acids. JD516897 - Sequence 497921 from Patent EP1572962. JD358465 - Sequence 339489 from Patent EP1572962. JD449046 - Sequence 430070 from Patent EP1572962. JD490812 - Sequence 471836 from Patent EP1572962. JD487945 - Sequence 468969 from Patent EP1572962. JD516613 - Sequence 497637 from Patent EP1572962. JD567079 - Sequence 548103 from Patent EP1572962. JD493810 - Sequence 474834 from Patent EP1572962. JD368805 - Sequence 349829 from Patent EP1572962. JD382805 - Sequence 363829 from Patent EP1572962. JD554118 - Sequence 535142 from Patent EP1572962. JD420056 - Sequence 401080 from Patent EP1572962. JD500751 - Sequence 481775 from Patent EP1572962. JD419117 - Sequence 400141 from Patent EP1572962. JD494755 - Sequence 475779 from Patent EP1572962. JD407825 - Sequence 388849 from Patent EP1572962. JD442389 - Sequence 423413 from Patent EP1572962. JD465968 - Sequence 446992 from Patent EP1572962. JD430800 - Sequence 411824 from Patent EP1572962. JD407838 - Sequence 388862 from Patent EP1572962. JD399727 - Sequence 380751 from Patent EP1572962. JD434336 - Sequence 415360 from Patent EP1572962. JD325347 - Sequence 306371 from Patent EP1572962. JD046992 - Sequence 28016 from Patent EP1572962. JD092946 - Sequence 73970 from Patent EP1572962. JD177729 - Sequence 158753 from Patent EP1572962. JD336198 - Sequence 317222 from Patent EP1572962. JD116024 - Sequence 97048 from Patent EP1572962. JD271458 - Sequence 252482 from Patent EP1572962. JD202049 - Sequence 183073 from Patent EP1572962. JD108400 - Sequence 89424 from Patent EP1572962. JD177576 - Sequence 158600 from Patent EP1572962. JD300752 - Sequence 281776 from Patent EP1572962. JD188784 - Sequence 169808 from Patent EP1572962. JD051890 - Sequence 32914 from Patent EP1572962. JD306867 - Sequence 287891 from Patent EP1572962. JD065741 - Sequence 46765 from Patent EP1572962. JD109738 - Sequence 90762 from Patent EP1572962. JD163443 - Sequence 144467 from Patent EP1572962. JD119845 - Sequence 100869 from Patent EP1572962. JD167944 - Sequence 148968 from Patent EP1572962. JD201602 - Sequence 182626 from Patent EP1572962. JD333470 - Sequence 314494 from Patent EP1572962. JD047152 - Sequence 28176 from Patent EP1572962. JD334586 - Sequence 315610 from Patent EP1572962. JD099866 - Sequence 80890 from Patent EP1572962. JD189158 - Sequence 170182 from Patent EP1572962. JD267442 - Sequence 248466 from Patent EP1572962. JD248008 - Sequence 229032 from Patent EP1572962. JD297936 - Sequence 278960 from Patent EP1572962. JD255594 - Sequence 236618 from Patent EP1572962. JD056449 - Sequence 37473 from Patent EP1572962. JD156923 - Sequence 137947 from Patent EP1572962. JD270764 - Sequence 251788 from Patent EP1572962. JD136952 - Sequence 117976 from Patent EP1572962. LF385291 - JP 2014500723-A/192794: Polycomb-Associated Non-Coding RNAs. LF345638 - JP 2014500723-A/153141: Polycomb-Associated Non-Coding RNAs. LF345639 - JP 2014500723-A/153142: Polycomb-Associated Non-Coding RNAs. MA620868 - JP 2018138019-A/192794: Polycomb-Associated Non-Coding RNAs. MA581215 - JP 2018138019-A/153141: Polycomb-Associated Non-Coding RNAs. MA581216 - JP 2018138019-A/153142: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00562 - Inositol phosphate metabolism hsa01100 - Metabolic pathways hsa04070 - Phosphatidylinositol signaling system
Reactome (by CSHL, EBI, and GO)
Protein Q9BTU6 (Reactome details) participates in the following event(s):
R-HSA-1675780 PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane R-HSA-1675974 PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane R-HSA-1676185 PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-1660516 Synthesis of PIPs at the early endosome membrane R-HSA-1660514 Synthesis of PIPs at the Golgi membrane R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism