Human Gene KIAA1529 (uc004axe.1)
  Description: hypothetical protein LOC57653
RefSeq Summary (NM_020893): The protein encoded by this gene contains a coiled-coil domain. Alternative splicing results in multiple transcript variants encoding different isoforms. A single nucleotide polymorphism (SNP) in this gene has been associated with increased susceptibility to Behcet's Disease (PMID: 19442274). [provided by RefSeq, Dec 2016].
Transcript (Including UTRs)
   Position: hg18 chr9:99,040,600-99,179,390 Size: 138,791 Total Exon Count: 49 Strand: +
Coding Region
   Position: hg18 chr9:99,093,505-99,178,997 Size: 85,493 Coding Exon Count: 38 

Page IndexSequence and LinksUniProtKB CommentsPrimersMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:99,040,600-99,179,390)mRNA (may differ from genome)Protein (1646 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CI174_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C9orf174;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=BAA96053.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH18175.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -330.82935-0.354 Picture PostScript Text
3' UTR -110.30393-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026701 - UPF_C9orf174

ModBase Predicted Comparative 3D Structure on Q9P1Z9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGD   SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK303497 - Homo sapiens cDNA FLJ60210 complete cds.
AK301827 - Homo sapiens cDNA FLJ50055 complete cds.
AB040962 - Homo sapiens mRNA for KIAA1529 protein, partial cds.
BC144521 - Homo sapiens KIAA1529, mRNA (cDNA clone MGC:178065 IMAGE:9053048), complete cds.
BC144522 - Homo sapiens cDNA clone IMAGE:9053049.
JD332886 - Sequence 313910 from Patent EP1572962.
JD255354 - Sequence 236378 from Patent EP1572962.
BC112930 - Homo sapiens KIAA1529, mRNA (cDNA clone IMAGE:6473441), complete cds.
BC047097 - Homo sapiens KIAA1529, mRNA (cDNA clone IMAGE:5268490), partial cds.
AK302965 - Homo sapiens cDNA FLJ50036 complete cds, weakly similar to Myosin-11.
CR749320 - Homo sapiens mRNA; cDNA DKFZp686B2031 (from clone DKFZp686B2031).
CU690374 - Synthetic construct Homo sapiens gateway clone IMAGE:100020954 5' read KIAA1529 mRNA.
CR627453 - Homo sapiens mRNA; cDNA DKFZp686G1725 (from clone DKFZp686G1725).
AK123391 - Homo sapiens cDNA FLJ41397 fis, clone BRCOC2019549.
AL137557 - Homo sapiens mRNA; cDNA DKFZp434I2420 (from clone DKFZp434I2420).
JD362245 - Sequence 343269 from Patent EP1572962.
KJ902992 - Synthetic construct Homo sapiens clone ccsbBroadEn_12386 BDAG1 gene, encodes complete protein.
JD282146 - Sequence 263170 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: K1529_HUMAN, NM_020893, NP_065944, Q2KHR6, Q5VV25, Q68DP5, Q69YV9, Q6AHY0, Q9P1Z9
UCSC ID: uc004axe.1
RefSeq Accession: NM_020893
Protein: Q9P1Z9 (aka CI174_HUMAN)
CCDS: CCDS35077.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020893.1
exon count: 49CDS single in 3' UTR: no RNA size: 6269
ORF size: 4941CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 8619.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.