ID:MUM1_HUMAN DESCRIPTION: RecName: Full=PWWP domain-containing protein MUM1; AltName: Full=Mutated melanoma-associated antigen 1; Short=MUM-1; AltName: Full=Protein expandere; FUNCTION: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. SUBUNIT: Interacts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes. SUBCELLULAR LOCATION: Nucleus. Note=Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1. DOMAIN: The PWWP domain mediates the interaction with nucleosomes. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: Acts as an antigenic peptide recognized by cytolytic T-lymphocytes in a melanoma (PubMed:7644523). SIMILARITY: Belongs to the MUM1 family. SIMILARITY: Contains 1 PWWP domain. SEQUENCE CAUTION: Sequence=AAC50240.1; Type=Frameshift; Positions=4; Sequence=AAH08098.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI10875.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB55357.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11493.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q2TAK8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
