Description: nitric oxide synthase 1 (neuronal) adaptor RefSeq Summary (NM_001126060): This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]. Transcript (Including UTRs) Position: hg18 chr1:160,599,397-160,606,437 Size: 7,041 Total Exon Count: 2 Strand: + Coding Region Position: hg18 chr1:160,599,737-160,599,886 Size: 150 Coding Exon Count: 1
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): NOS1AP CDC HuGE Published Literature: NOS1AP Positive Disease Associations: cardiac death QT interval Related Studies:
cardiac death QT interval Aarnoudse, A. J. et al. 2007, Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study, Circulation 2007.
[PubMed 17576865]
Common variants in NOS1AP are strongly associated with QT-interval duration in an elderly population. Larger sample sizes are needed to confirm or exclude an effect on sudden cardiac death risk.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC041382 - Homo sapiens nitric oxide synthase 1 (neuronal) adaptor protein, mRNA (cDNA clone IMAGE:5275285). AB007933 - Homo sapiens KIAA0464 mRNA for KIAA0464 protein. BC112295 - Homo sapiens nitric oxide synthase 1 (neuronal) adaptor protein, mRNA (cDNA clone MGC:138500 IMAGE:8327763), complete cds. BC143771 - Homo sapiens cDNA clone MGC:177302 IMAGE:9052285, complete cds. BC143780 - Homo sapiens cDNA clone IMAGE:9052294. BC111928 - Synthetic construct Homo sapiens clone IMAGE:40080755, MGC:133468 NOS1AP protein (NOS1AP) mRNA, encodes complete protein. BC118499 - Synthetic construct Homo sapiens clone IMAGE:40080763, MGC:155336 NOS1AP protein (NOS1AP) mRNA, encodes complete protein. AB587549 - Synthetic construct DNA, clone: pF1KE1067, Homo sapiens NOS1AP gene for nitric oxide synthase 1 (neuronal) adaptor protein, without stop codon, in Flexi system. AY841899 - Homo sapiens CAPON short form mRNA, complete cds, alternatively spliced. AF037070 - Homo sapiens carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase mRNA, partial cds. JD424606 - Sequence 405630 from Patent EP1572962. JD488227 - Sequence 469251 from Patent EP1572962. JD390195 - Sequence 371219 from Patent EP1572962. JD384187 - Sequence 365211 from Patent EP1572962. JD443118 - Sequence 424142 from Patent EP1572962. JD465882 - Sequence 446906 from Patent EP1572962. JD420963 - Sequence 401987 from Patent EP1572962. JD484046 - Sequence 465070 from Patent EP1572962. JD138726 - Sequence 119750 from Patent EP1572962. JD228748 - Sequence 209772 from Patent EP1572962. JD158090 - Sequence 139114 from Patent EP1572962. JD232891 - Sequence 213915 from Patent EP1572962. JD300540 - Sequence 281564 from Patent EP1572962. JD255154 - Sequence 236178 from Patent EP1572962. JD323232 - Sequence 304256 from Patent EP1572962.