Description: protein phosphatase 1, regulatory (inhibitor) RefSeq Summary (NM_021959): This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg18 chr6_qbl_hap2:1,281,858-1,285,034 Size: 3,177 Total Exon Count: 3 Strand: + Coding Region Position: hg18 chr6_qbl_hap2:1,282,114-1,284,009 Size: 1,896 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07491 - Protein phosphatase inhibitor
ModBase Predicted Comparative 3D Structure on O60927
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004864 protein phosphatase inhibitor activity GO:0004865 protein serine/threonine phosphatase inhibitor activity GO:0005515 protein binding GO:0008157 protein phosphatase 1 binding GO:0016740 transferase activity GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0016567 protein ubiquitination GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0050710 negative regulation of cytokine secretion GO:0050830 defense response to Gram-positive bacterium
US Server
Sequence and Links to Tools and Databases 
