Description: mitochondrial ribosomal protein 63 RefSeq Summary (NM_024026): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg18 chr13:20,648,372-20,651,220 Size: 2,849 Total Exon Count: 2 Strand: + Coding Region Position: hg18 chr13:20,649,056-20,649,364 Size: 309 Coding Exon Count: 1
ID:RT63_HUMAN DESCRIPTION: RecName: Full=Ribosomal protein 63, mitochondrial; Short=hMRP63; SUBCELLULAR LOCATION: Mitochondrion (By similarity). MISCELLANEOUS: Identified only in the intact 55S subunit. It is unknown whether it belongs to the 28S or to the 39S subunit. May localize at the subunit interface and dissociate from the 55S mitoribosome during subunit separation.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BQC6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC068492 - Homo sapiens mitochondrial ribosomal protein 63, mRNA (cDNA clone MGC:87182 IMAGE:4801279), complete cds. BC023616 - Homo sapiens mitochondrial ribosomal protein 63, mRNA (cDNA clone MGC:23340 IMAGE:4645641), complete cds. BC000002 - Homo sapiens mitochondrial ribosomal protein 63, mRNA (cDNA clone IMAGE:3505092), with apparent retained intron. AB049957 - Homo sapiens bMRP63 mRNA for mitochondrial ribosomal protein bMRP63, complete cds. DQ895281 - Synthetic construct Homo sapiens clone IMAGE:100009741; FLH184620.01L; RZPDo839A02145D mitochondrial ribosomal protein 63 (MRP63) gene, encodes complete protein; nuclear gene for mitochondrial product. DQ892088 - Synthetic construct clone IMAGE:100004718; FLH184624.01X; RZPDo839A02146D mitochondrial ribosomal protein 63 (MRP63) gene, encodes complete protein; nuclear gene for mitochondrial product. JD446612 - Sequence 427636 from Patent EP1572962. JD362327 - Sequence 343351 from Patent EP1572962. JD489808 - Sequence 470832 from Patent EP1572962. JD447072 - Sequence 428096 from Patent EP1572962. JD468877 - Sequence 449901 from Patent EP1572962. JD453175 - Sequence 434199 from Patent EP1572962. JD431427 - Sequence 412451 from Patent EP1572962. JD529589 - Sequence 510613 from Patent EP1572962. JD501338 - Sequence 482362 from Patent EP1572962. JD534108 - Sequence 515132 from Patent EP1572962. JD442277 - Sequence 423301 from Patent EP1572962. JD354273 - Sequence 335297 from Patent EP1572962. KJ899506 - Synthetic construct Homo sapiens clone ccsbBroadEn_08900 MRP63 gene, encodes complete protein. JD321538 - Sequence 302562 from Patent EP1572962. JD180693 - Sequence 161717 from Patent EP1572962. JD338479 - Sequence 319503 from Patent EP1572962. JD225474 - Sequence 206498 from Patent EP1572962. JD262929 - Sequence 243953 from Patent EP1572962. JD285967 - Sequence 266991 from Patent EP1572962. JD101721 - Sequence 82745 from Patent EP1572962. JD319777 - Sequence 300801 from Patent EP1572962. JD244278 - Sequence 225302 from Patent EP1572962. JD108197 - Sequence 89221 from Patent EP1572962. JD047718 - Sequence 28742 from Patent EP1572962. JD266491 - Sequence 247515 from Patent EP1572962. JD344071 - Sequence 325095 from Patent EP1572962. JD178667 - Sequence 159691 from Patent EP1572962. JD133667 - Sequence 114691 from Patent EP1572962. JD170017 - Sequence 151041 from Patent EP1572962. JD306758 - Sequence 287782 from Patent EP1572962. JD292295 - Sequence 273319 from Patent EP1572962. JD138095 - Sequence 119119 from Patent EP1572962. JD064930 - Sequence 45954 from Patent EP1572962. JD177335 - Sequence 158359 from Patent EP1572962. JD271329 - Sequence 252353 from Patent EP1572962. JD231942 - Sequence 212966 from Patent EP1572962. JD283400 - Sequence 264424 from Patent EP1572962. JD199370 - Sequence 180394 from Patent EP1572962. MN309624 - Homo sapiens LNC_000987 lncRNA, complete sequence.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BQC6 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins