ID:UFD1_MOUSE DESCRIPTION: RecName: Full=Ubiquitin fusion degradation protein 1 homolog; Short=UB fusion protein 1; FUNCTION: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). It may be involved in the development of some ectoderm-derived structures. PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. SUBUNIT: Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm, cytosol (By similarity). DEVELOPMENTAL STAGE: Expressed at high levels in the otocyst (between E9.5 and E11.5 embryos fading away after E12) and in the developing eye. Lower expression is found in different sites of the embryos such as developing brain, the lungs and the cardiac outflow tract. SIMILARITY: Belongs to the UFD1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03152 - Ubiquitin fusion degradation protein UFD1
ModBase Predicted Comparative 3D Structure on P70362
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0030970 retrograde protein transport, ER to cytosol GO:0032480 negative regulation of type I interferon production GO:0039536 negative regulation of RIG-I signaling pathway GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0071712 ER-associated misfolded protein catabolic process
Protein P70362 (Reactome details) participates in the following event(s):
R-MMU-5654985 SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH R-MMU-6781922 USP13 binds UFD1L:SKP2 R-MMU-5654989 SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA R-MMU-110320 Translesion Synthesis by POLH R-MMU-5689880 Ub-specific processing proteases R-MMU-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-MMU-5688426 Deubiquitination R-MMU-73893 DNA Damage Bypass R-MMU-597592 Post-translational protein modification R-MMU-73894 DNA Repair R-MMU-392499 Metabolism of proteins
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