Mouse Gene Hsd17b6 (ENSMUST00000026462.7) from GENCODE VM30
  Description: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). (from UniProt Q9R092)
Gencode Transcript: ENSMUST00000026462.7
Gencode Gene: ENSMUSG00000025396.8
Transcript (Including UTRs)
   Position: mm39 chr10:127,826,810-127,836,547 Size: 9,738 Total Exon Count: 5 Strand: -
Coding Region
   Position: mm39 chr10:127,827,117-127,833,879 Size: 6,763 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2022-06-02 09:33:23

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:127,826,810-127,836,547)mRNA (may differ from genome)Protein (317 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
ReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: H17B6_MOUSE
DESCRIPTION: RecName: Full=17-beta-hydroxysteroid dehydrogenase type 6; Short=17-beta-HSD 6; Short=17-beta-HSD6; EC=1.1.1.105; EC=1.1.1.62; EC=1.1.1.63; AltName: Full=17-beta-HSD9; AltName: Full=3-alpha->beta-hydroxysteroid epimerase; Short=3-alpha->beta-HSE; AltName: Full=Oxidative 3-alpha hydroxysteroid dehydrogenase; Flags: Precursor;
FUNCTION: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro).
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.
CATALYTIC ACTIVITY: Testosterone + NAD(+) = androst-4-ene-3,17- dione + NADH.
CATALYTIC ACTIVITY: All-trans-retinol-[cellular-retinol-binding- protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding- protein] + NADH.
SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side (Potential).
TISSUE SPECIFICITY: Detected in liver.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.50131-0.324 Picture PostScript Text
3' UTR -59.40307-0.193 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
IPR020904 - Sc_DH/Rdtase_CS

Pfam Domains:
PF00106 - short chain dehydrogenase

ModBase Predicted Comparative 3D Structure on Q9R092
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD  WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity

Biological Process:
GO:0006629 lipid metabolic process
GO:0008202 steroid metabolic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0031090 organelle membrane
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC021836 - Mus musculus hydroxysteroid (17-beta) dehydrogenase 6, mRNA (cDNA clone MGC:30306 IMAGE:5135142), complete cds.
AK008212 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010012N05 product:hydroxysteroid 17-beta dehydrogenase 9, full insert sequence.
AF103797 - Mus musculus trans-retinol/estrogen dehydrogenase (Rdh8) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9R092 (Reactome details) participates in the following event(s):

R-MMU-2454081 RDH5 oxidises 11cROL to 11cRAL
R-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-2187338 Visual phototransduction
R-MMU-418594 G alpha (i) signalling events
R-MMU-388396 GPCR downstream signalling
R-MMU-372790 Signaling by GPCR
R-MMU-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000026462.1, ENSMUST00000026462.2, ENSMUST00000026462.3, ENSMUST00000026462.4, ENSMUST00000026462.5, ENSMUST00000026462.6, Gm182, H17B6_MOUSE, Hsd17b9, Q9R092, Rdh8, uc287vpt.1, uc287vpt.2
UCSC ID: ENSMUST00000026462.7
RefSeq Accession: NM_013786
Protein: Q9R092 (aka H17B6_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.