Mouse Gene Hsd17b6 (ENSMUST00000026462.7) from GENCODE VM30
Description: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). (from UniProt Q9R092) Gencode Transcript: ENSMUST00000026462.7 Gencode Gene: ENSMUSG00000025396.8 Transcript (Including UTRs) Position: mm39 chr10:127,826,810-127,836,547 Size: 9,738 Total Exon Count: 5 Strand: - Coding Region Position: mm39 chr10:127,827,117-127,833,879 Size: 6,763 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9R092
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.