Mouse Gene Casp9 (ENSMUST00000030747.11) from GENCODE VM33
Description: Mus musculus caspase 9 (Casp9), transcript variant 1, mRNA. (from RefSeq NM_015733) RefSeq Summary (NM_015733): This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, the initiator caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]. Gencode Transcript: ENSMUST00000030747.11 Gencode Gene: ENSMUSG00000028914.14 Transcript (Including UTRs) Position: mm39 chr4:141,520,923-141,543,287 Size: 22,365 Total Exon Count: 9 Strand: + Coding Region Position: mm39 chr4:141,521,166-141,540,998 Size: 19,833 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8C3Q9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004197 cysteine-type endopeptidase activity GO:0005515 protein binding GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0016787 hydrolase activity GO:0017124 SH3 domain binding GO:0019901 protein kinase binding GO:0042802 identical protein binding GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process: GO:0006508 proteolysis GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006974 cellular response to DNA damage stimulus GO:0007568 aging GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009411 response to UV GO:0014070 response to organic cyclic compound GO:0032025 response to cobalt ion GO:0032355 response to estradiol GO:0032496 response to lipopolysaccharide GO:0034349 glial cell apoptotic process GO:0034644 cellular response to UV GO:0042770 signal transduction in response to DNA damage GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0046677 response to antibiotic GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0071407 cellular response to organic cyclic compound GO:0071549 cellular response to dexamethasone stimulus GO:0097194 execution phase of apoptosis GO:2001020 regulation of response to DNA damage stimulus
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