Mouse Gene Stk10 (ENSMUST00000102821.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus serine/threonine kinase 10 (Stk10), transcript variant 1, mRNA. (from RefSeq NM_009288) RefSeq Summary (NM_009288): This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENSMUST00000102821.3 Gencode Gene: ENSMUSG00000020272.8 Transcript (Including UTRs) Position: mm10 chr11:32,533,305-32,624,587 Size: 91,283 Total Exon Count: 19 Strand: + Coding Region Position: mm10 chr11:32,533,404-32,622,561 Size: 89,158 Coding Exon Count: 19
ID:STK10_MOUSE DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 10; EC=2.7.11.1; AltName: Full=Lymphocyte-oriented kinase; FUNCTION: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib (By similarity). SUBUNIT: Homodimer; homodimerization is required for activation segment autophosphorylation (By similarity). SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Expressed predominantly in lymphoid organs such as spleen, thymus, and bone marrow. PTM: Autophosphorylates following homodimerization, leading to activation of the protein (By similarity). DISRUPTION PHENOTYPE: Mice do not show any obvious abnormalities. Lymphocytes develop normally but activated lymphocytes show enhanced cell adhesion. Decreased phosphorylation of ERM proteins. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase PF12474 - Polo kinase kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on O55098
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0007049 cell cycle GO:0007346 regulation of mitotic cell cycle GO:0016310 phosphorylation GO:0023014 signal transduction by protein phosphorylation GO:0031098 stress-activated protein kinase signaling cascade GO:0032147 activation of protein kinase activity GO:0042981 regulation of apoptotic process GO:0046777 protein autophosphorylation GO:0071593 lymphocyte aggregation GO:2000401 regulation of lymphocyte migration
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