ID:UBE2Z_MOUSE DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 Z; EC=6.3.2.19; AltName: Full=Uba6-specific E2 conjugating enzyme 1; Short=Use1; AltName: Full=Ubiquitin carrier protein Z; AltName: Full=Ubiquitin-protein ligase Z; FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation (By similarity). CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SEQUENCE CAUTION: Sequence=AAH54412.1; Type=Erroneous initiation; Sequence=BAB24097.1; Type=Erroneous initiation; Sequence=BAC37014.1; Type=Frameshift; Positions=115;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3UE37
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0016740 transferase activity GO:0031625 ubiquitin protein ligase binding GO:0061630 ubiquitin protein ligase activity GO:0061631 ubiquitin conjugating enzyme activity
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0006915 apoptotic process GO:0016567 protein ubiquitination GO:0043065 positive regulation of apoptotic process
AK077793 - Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830473M12 product:hypothetical Ubiquitin-conjugating enzymes containing protein, full insert sequence. BC054412 - Mus musculus ubiquitin-conjugating enzyme E2Z (putative), mRNA (cDNA clone MGC:62703 IMAGE:2646768), complete cds. AK152529 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830078F06 product:tripartite motif protein 34, full insert sequence. AK168942 - Mus musculus 17 days pregnant adult female amnion cDNA, RIKEN full-length enriched library, clone:I920066K10 product:tripartite motif protein 34, full insert sequence. AK153328 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830138O19 product:hypothetical Ubiquitin-conjugating enzymes containing protein, full insert sequence. AK149770 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530015K19 product:tripartite motif protein 34, full insert sequence. BC027266 - Mus musculus ubiquitin-conjugating enzyme E2Z (putative), mRNA (cDNA clone IMAGE:2648305), with apparent retained intron. AK005524 - Mus musculus adult female placenta cDNA, RIKEN full-length enriched library, clone:1600023F01 product:hypothetical Ubiquitin-conjugating enzymes containing protein, full insert sequence. AK180585 - Mus musculus cDNA, clone:Y0G0114P10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK211733 - Mus musculus cDNA, clone:Y2G0122L02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK212499 - Mus musculus cDNA, clone:Y2G0125C15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK212571 - Mus musculus cDNA, clone:Y2G0125G15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK180312 - Mus musculus cDNA, clone:Y0G0113L06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK187506 - Mus musculus cDNA, clone:Y0G0142B15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK208933 - Mus musculus cDNA, clone:Y2G0113E14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK182447 - Mus musculus cDNA, clone:Y0G0122A13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search. AK047807 - Mus musculus adult male corpus striatum cDNA, RIKEN full-length enriched library, clone:C030047H17 product:unclassifiable, full insert sequence. AK203763 - Mus musculus cDNA, clone:Y1G0146B15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014493, based on BLAT search.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04120 - Ubiquitin mediated proteolysis
Reactome (by CSHL, EBI, and GO)
Protein Q3UE37 (Reactome details) participates in the following event(s):
R-MMU-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes R-MMU-983152 Transfer of ubiquitin from E1 to E2 R-MMU-983140 Transfer of Ub from E2 to substrate and release of E2 R-MMU-983157 Interaction of E3 with substrate and E2-Ub complex R-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation R-MMU-8852135 Protein ubiquitination R-MMU-983169 Class I MHC mediated antigen processing & presentation R-MMU-597592 Post-translational protein modification R-MMU-1280218 Adaptive Immune System R-MMU-392499 Metabolism of proteins R-MMU-168256 Immune System
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