Mouse Gene Stam2 (ENSMUST00000102759.7) Description and Page Index
  Description: Mus musculus signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 (Stam2), mRNA. (from RefSeq NM_019667)
Gencode Transcript: ENSMUST00000102759.7
Gencode Gene: ENSMUSG00000055371.17
Transcript (Including UTRs)
   Position: mm10 chr2:52,691,664-52,742,200 Size: 50,537 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm10 chr2:52,694,709-52,742,100 Size: 47,392 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:52,691,664-52,742,200)mRNA (may differ from genome)Protein (523 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q3TGH8_MOUSE
DESCRIPTION: SubName: Full=Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; SubName: Full=Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, isoform CRA_a; SubName: Full=Stam2;
SIMILARITY: Contains 1 SH3 domain.
SIMILARITY: Contains 1 VHS domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.30100-0.473 Picture PostScript Text
3' UTR -832.503045-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008942 - ENTH_VHS
IPR000108 - p67phox
IPR001452 - SH3_domain
IPR003903 - Ubiquitin-int_motif
IPR002014 - VHS
IPR018205 - VHS_subgr

Pfam Domains:
PF00018 - SH3 domain
PF00790 - VHS domain
PF02809 - Ubiquitin interaction motif
PF07653 - Variant SH3 domain
PF14604 - Variant SH3 domain

SCOP Domains:
48371 - ARM repeat
48464 - ENTH/VHS domain
89009 - GAT-like domain
50044 - SH3-domain
102829 - Cell division protein ZapA-like

ModBase Predicted Comparative 3D Structure on Q3TGH8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsembl  SGD
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006886 intracellular protein transport

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK035789 - Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630004H24 product:signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, full insert sequence.
AK004604 - Mus musculus adult male lung cDNA, RIKEN full-length enriched library, clone:1200004O12 product:signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, full insert sequence.
BC013818 - Mus musculus signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, mRNA (cDNA clone MGC:18336 IMAGE:3671426), complete cds.
AK159699 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420028H23 product:signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, full insert sequence.
AK168729 - Mus musculus 17 days pregnant adult female amnion cDNA, RIKEN full-length enriched library, clone:I920048C22 product:signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, full insert sequence.
AB012611 - Mus musculus Hbp mRNA for Hrs binding Protein, complete cds.
AK188839 - Mus musculus cDNA, clone:Y0G0146K08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000028330, based on BLAT search.
AK044230 - Mus musculus adult retina cDNA, RIKEN full-length enriched library, clone:A930002G24 product:signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, full insert sequence.
AK178358 - Mus musculus cDNA, clone:Y0G0106G12, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000028330, based on BLAT search.
AK078244 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430533F08 product:signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, full insert sequence.
DQ141211 - Mus musculus signal transducing adaptor molecule 2 (Stam2) mRNA, complete cds, alternatively spliced.
AK214650 - Mus musculus cDNA, clone:Y2G0132I01, strand:unspecified.
AK017668 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730456G07 product:signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04144 - Endocytosis
mmu04630 - Jak-STAT signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_9874, NM_019667, Q3TGH8, Q3TGH8_MOUSE, RP23-413K16.1-001, uc008jre.1, uc008jre.2
UCSC ID: uc008jre.2
RefSeq Accession: NM_019667
Protein: Q3TGH8 CCDS: CCDS16037.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.