Mouse Gene Ddx27 (ENSMUST00000018143.15) Description and Page Index
  Description: Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (Ddx27), mRNA. (from RefSeq NM_153065)
Gencode Transcript: ENSMUST00000018143.15
Gencode Gene: ENSMUSG00000017999.16
Transcript (Including UTRs)
   Position: mm10 chr2:167,015,193-167,034,947 Size: 19,755 Total Exon Count: 21 Strand: +
Coding Region
   Position: mm10 chr2:167,015,334-167,034,657 Size: 19,324 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:167,015,193-167,034,947)mRNA (may differ from genome)Protein (760 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DDX27_MOUSE
DESCRIPTION: RecName: Full=Probable ATP-dependent RNA helicase DDX27; EC=3.6.4.13; AltName: Full=DEAD box protein 27;
FUNCTION: Probable ATP-dependent RNA helicase.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
SEQUENCE CAUTION: Sequence=AAH11321.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.10141-0.426 Picture PostScript Text
3' UTR -77.80290-0.268 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR000629 - RNA-helicase_DEAD-box_CS
IPR014014 - RNA_helicase_DEAD_Q_motif

Pfam Domains:
PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain
PF04851 - Type III restriction enzyme, res subunit

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q921N6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Biological Process:
GO:0006364 rRNA processing
GO:0010501 RNA secondary structure unwinding
GO:0042254 ribosome biogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK138442 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230109E14 product:DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, full insert sequence.
AK146469 - Mus musculus 16 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920009I10 product:DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, full insert sequence.
BC024730 - Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, mRNA (cDNA clone IMAGE:5366188), complete cds.
BC024981 - Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, mRNA (cDNA clone IMAGE:5362490).
BC033398 - Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, mRNA (cDNA clone IMAGE:5363914), partial cds.
AK134274 - Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930425H22 product:DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, full insert sequence.
AK189161 - Mus musculus cDNA, clone:Y0G0148B07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000045557, based on BLAT search.
BC011321 - Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, mRNA (cDNA clone MGC:18747 IMAGE:4007058), complete cds.
AK182136 - Mus musculus cDNA, clone:Y0G0120P11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000018143, based on BLAT search.
AK195653 - Mus musculus cDNA, clone:Y1G0119D06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000018143, based on BLAT search.
AK205436 - Mus musculus cDNA, clone:Y2G0101K21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000018143, based on BLAT search.
AK214083 - Mus musculus cDNA, clone:Y2G0130J04, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000018143, based on BLAT search.
BC026381 - Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, mRNA (cDNA clone IMAGE:4167383), partial cds.
AK209187 - Mus musculus cDNA, clone:Y2G0114E10, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000018143, based on BLAT search.
AK218996 - Mus musculus cDNA, clone:Y2G0147A08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000018143, based on BLAT search.
AK205954 - Mus musculus cDNA, clone:Y2G0103E24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000018143, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: DDX27_MOUSE, NM_153065, Q3UUG2, Q8R0W3, Q8R1E2, Q921N6, uc008nzb.1, uc008nzb.2
UCSC ID: uc008nzb.2
RefSeq Accession: NM_153065
Protein: Q921N6 (aka DDX27_MOUSE or DD27_MOUSE)
CCDS: CCDS38336.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.