Mouse Gene Sf3b4 (ENSMUST00000076372.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus splicing factor 3b, subunit 4 (Sf3b4), mRNA. (from RefSeq NM_153053) RefSeq Summary (NM_153053): This gene encodes one of the subunits of splicing factor 3B. A similar gene in human encodes a protein that cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes, and also belongs with the minor U12-dependent spliceosome. [provided by RefSeq, May 2015]. Gencode Transcript: ENSMUST00000076372.4 Gencode Gene: ENSMUSG00000068856.3 Transcript (Including UTRs) Position: mm10 chr3:96,172,332-96,177,564 Size: 5,233 Total Exon Count: 6 Strand: + Coding Region Position: mm10 chr3:96,172,574-96,177,166 Size: 4,593 Coding Exon Count: 6
ID:SF3B4_MOUSE DESCRIPTION: RecName: Full=Splicing factor 3B subunit 4; FUNCTION: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity). SUBUNIT: Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. SF3B4 interacts directly with SF3B2 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the SF3B4 family. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8QZY9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC026567 - Mus musculus splicing factor 3b, subunit 4, mRNA (cDNA clone MGC:36369 IMAGE:4982239), complete cds. AK135543 - Mus musculus 12 days embryo female mullerian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6820446N04 product:splicing factor 3b, subunit 4, full insert sequence. AK156828 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830102F05 product:splicing factor 3b, subunit 4, full insert sequence. AK047751 - Mus musculus adult male corpus striatum cDNA, RIKEN full-length enriched library, clone:C030024J07 product:SPLICING FACTOR 3B SUBUNIT 4 (SPLICEOSOME ASSOCIATED PROTEIN 49) (SAP 49) (SF3B50) (PRE-MRNA SPLICING FACTOR SF3B 49 KDA SUBUNIT) homolog [Homo sapiens], full insert sequence. BC085273 - Mus musculus splicing factor 3b, subunit 4, mRNA (cDNA clone MGC:103360 IMAGE:30144329), complete cds. AK180912 - Mus musculus cDNA, clone:Y0G0116E24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000061281, based on BLAT search. AK205335 - Mus musculus cDNA, clone:Y2G0101F24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000061281, based on BLAT search. AK179825 - Mus musculus cDNA, clone:Y0G0111N05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000071088, based on BLAT search. AK184895 - Mus musculus cDNA, clone:Y0G0131O03, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000071088, based on BLAT search. AK187332 - Mus musculus cDNA, clone:Y0G0141E16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000071088, based on BLAT search. AK199300 - Mus musculus cDNA, clone:Y1G0130M06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000061281, based on BLAT search. AK204251 - Mus musculus cDNA, clone:Y1G0147L24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000061281, based on BLAT search. AK201422 - Mus musculus cDNA, clone:Y1G0138D15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000061281, based on BLAT search.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein Q8QZY9 (Reactome details) participates in the following event(s):
R-MMU-75080 Formation of AT-AC A complex R-MMU-72127 Formation of the Spliceosomal B Complex R-MMU-72139 Formation of the active Spliceosomal C (B*) complex R-MMU-72143 Lariat Formation and 5'-Splice Site Cleavage R-MMU-156661 Formation of Exon Junction Complex R-MMU-75081 Formation of AT-AC B Complex R-MMU-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage R-MMU-72165 mRNA Splicing - Minor Pathway R-MMU-72163 mRNA Splicing - Major Pathway R-MMU-72172 mRNA Splicing R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA R-MMU-8953854 Metabolism of RNA
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