Mouse Gene Arpc1a (ENSMUST00000031625.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus actin related protein 2/3 complex, subunit 1A (Arpc1a), mRNA. (from RefSeq NM_019767)
Gencode Transcript: ENSMUST00000031625.14
Gencode Gene: ENSMUSG00000029621.14
Transcript (Including UTRs)
   Position: mm10 chr5:145,083,830-145,108,761 Size: 24,932 Total Exon Count: 10 Strand: +
Coding Region
   Position: mm10 chr5:145,091,183-145,108,415 Size: 17,233 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:145,083,830-145,108,761)mRNA (may differ from genome)Protein (370 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ARC1A_MOUSE
DESCRIPTION: RecName: Full=Actin-related protein 2/3 complex subunit 1A; AltName: Full=SOP2-like protein; AltName: Full=Sid 329;
FUNCTION: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
SUBUNIT: Probable component of the Arp2/3 complex in which it may replace ARPC1B.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
SIMILARITY: Belongs to the WD repeat ARPC1 family.
SIMILARITY: Contains 6 WD repeats.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.60173-0.287 Picture PostScript Text
3' UTR -95.40346-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017383 - ARPC2/3_su1
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
89372 - Fucose-specific lectin
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
110296 - Oligoxyloglucan reducing end-specific cellobiohydrolase
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9R0Q6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051015 actin filament binding

Biological Process:
GO:0030833 regulation of actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0015629 actin cytoskeleton
GO:0036195 muscle cell projection membrane


-  Descriptions from all associated GenBank mRNAs
  AB024984 - Mus musculus Sid329 mRNA, complete cds.
AK003986 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110030K07 product:actin related protein 2/3 complex, subunit 1A (41 kDa), full insert sequence.
AK145663 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0027I17 product:actin related protein 2/3 complex, subunit 1A, full insert sequence.
AK076107 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810052C02 product:actin related protein 2/3 complex, subunit 1A (41 kDa), full insert sequence.
BC001988 - Mus musculus actin related protein 2/3 complex, subunit 1A, mRNA (cDNA clone MGC:5680 IMAGE:3485409), complete cds.
AK002475 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610010H08 product:actin related protein 2/3 complex, subunit 1A (41 kDa), full insert sequence.
AK183888 - Mus musculus cDNA, clone:Y0G0127L10, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000031625, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04666 - Fc gamma R-mediated phagocytosis
mmu04810 - Regulation of actin cytoskeleton
mmu05100 - Bacterial invasion of epithelial cells

Reactome (by CSHL, EBI, and GO)

Protein Q9R0Q6 (Reactome details) participates in the following event(s):

R-MMU-3928595 N-WASP binds ARP2/3 and G-actin
R-MMU-8868230 SNX9 recruits components of the actin polymerizing machinery
R-MMU-1861595 Extension of pseudopodia by myosin-X in a PI3K dependent manner
R-MMU-2029466 Attachment of preexisting mother filament and initiation of branching
R-MMU-2197690 Detachment of WASP/WAVE
R-MMU-8868236 BAR domain proteins recruit dynamin
R-MMU-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission
R-MMU-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P
R-MMU-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
R-MMU-8871194 RAB5 and GAPVD1 bind AP-2
R-MMU-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle
R-MMU-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-2682334 EPH-Ephrin signaling
R-MMU-199991 Membrane Trafficking
R-MMU-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-MMU-195258 RHO GTPase Effectors
R-MMU-422475 Axon guidance
R-MMU-5653656 Vesicle-mediated transport
R-MMU-168249 Innate Immune System
R-MMU-194315 Signaling by Rho GTPases
R-MMU-1266738 Developmental Biology
R-MMU-168256 Immune System
R-MMU-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ARC1A_MOUSE, NM_019767, Q3UL75, Q9R0Q6, Sid329, uc009ama.1, uc009ama.2
UCSC ID: uc009ama.2
RefSeq Accession: NM_019767
Protein: Q9R0Q6 (aka ARC1A_MOUSE)
CCDS: CCDS19855.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.