Rat Gene Sox6 (RGD:1309000) Description and Page Index
  Description: overexpression induces astrocyte differentiation
Transcript (Including UTRs)
   Position: rn4 chr1:173,556,966-174,069,437 Size: 512,472 Total Exon Count: 16 Strand: -
Coding Region
   Position: rn4 chr1:173,557,165-173,871,068 Size: 313,904 Coding Exon Count: 14 

Page IndexSequence and LinksRGD Gene DataCTDMicroarray ExpressionProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:173,556,966-174,069,437)mRNAProtein (787 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed
ReactomeRGDStanford SOURCEUniProtKB

-  Additional Data from RGD
  RGD Gene: 1309000
Gene Symbol: Sox6
Name: SRY (sex determining region Y)-box 6
Curated Pubmed Papers: 12081133, 12477932, 15565366, 15846364, 16148004, 19690046
Uncurated Pubmed Papers: 1581115, 1581307, 1580007, 1580857
Entrez Gene: 293165
UniProt: Q4V8G3
GenBank Nucleotide: CH473956, NM_001024751, BC097403
Genebank Protein: AAH97403, EDM17750, EDM17751, EDM17752, NP_001019922, Q4V8G3, NP_001019922.1
UniGene: 76073
Ensembl Gene: ENSRNOG00000020514, ENSRNOG00000020514
IMAGE CLONE: 7453944
MGC: BC097403

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

Affymetrix All Exon Microarrays


-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009071 - HMG_superfamily

Pfam Domains:
PF00505 - HMG (high mobility group) box

ModBase Predicted Comparative 3D Structure on Q4V8G3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
  Ensembl WormBase 
  Protein Sequence Protein Sequence 
  Alignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0048708 astrocyte differentiation

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  BC097403 - Rattus norvegicus SRY (sex determining region Y)-box 6, mRNA (cDNA clone MGC:114448 IMAGE:7453944), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q4V8G3 (Reactome details) participates in the following event(s):

R-RNO-5626938 Beta-catenin binds SOX proteins
R-RNO-3769402 Deactivation of the beta-catenin transactivating complex
R-RNO-201681 TCF dependent signaling in response to WNT
R-RNO-195721 Signaling by WNT
R-RNO-162582 Signal Transduction

-  Other Names for This Gene
  Symbol: Sox6_predicted
Name: SRY (sex determining region Y)-box 6, SRY-box containing gene 6, SRY-box containing gene 6 (predicted), transcription factor SOX-6
RefSeq Accession: NM_001024751
Protein: Q4V8G3

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.