Human Gene OBSCN (ENST00000680850.1) from GENCODE V44
Description: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (from HGNC OBSCN) RefSeq Summary (NM_001271223): The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000680850.1 Gencode Gene: ENSG00000154358.23 Transcript (Including UTRs) Position: hg38 chr1:228,208,044-228,378,876 Size: 170,833 Total Exon Count: 116 Strand: + Coding Region Position: hg38 chr1:228,211,784-228,378,795 Size: 167,012 Coding Exon Count: 115
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
