Description: claudin 18 RefSeq Summary (NM_019815): This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010]. Transcript (Including UTRs) Position: mm8 chr9:99,500,151-99,519,367 Size: 19,217 Total Exon Count: 5 Strand: - Coding Region Position: mm8 chr9:99,502,075-99,519,300 Size: 17,226 Coding Exon Count: 5
ID:CLD18_MOUSE DESCRIPTION: RecName: Full=Claudin-18; FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the claudin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00822 - PMP-22/EMP/MP20/Claudin family
ModBase Predicted Comparative 3D Structure on P56857
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005198 structural molecule activity GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0045471 response to ethanol GO:0045779 negative regulation of bone resorption GO:0048565 digestive tract development GO:0071847 TNFSF11-mediated signaling pathway GO:1900181 negative regulation of protein localization to nucleus GO:2001205 negative regulation of osteoclast development
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