Description: Homo sapiens calcium/calmodulin-dependent protein kinase II beta (CAMK2B), transcript variant 8, mRNA. RefSeq Summary (NM_172084): The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. Transcript (Including UTRs) Position: hg19 chr7:44,256,749-44,365,230 Size: 108,482 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr7:44,259,661-44,365,020 Size: 105,360 Coding Exon Count: 15
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CAMK2B CDC HuGE Published Literature: CAMK2B Positive Disease Associations: Metabolic Syndrome X Related Studies:
Metabolic Syndrome X Kati Kristiansson et al. Circulation. Cardiovascular genetics 2012, Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits., Circulation. Cardiovascular genetics.
[PubMed 22399527]
Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and glucose intolerance.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase PF08332 - Calcium/calmodulin dependent protein kinase II association domain PF13474 - SnoaL-like domain PF14534 - Domain of unknown function (DUF4440)
ModBase Predicted Comparative 3D Structure on Q13554-7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK290148 - Homo sapiens cDNA FLJ75317 complete cds, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase (CaM kinase) II beta (CAMK2B), transcript variant 2, mRNA. AK294138 - Homo sapiens cDNA FLJ58056 complete cds, highly similar to Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17). AJ252237 - Homo sapiens mRNA for calcium/calmodulin dependent protein kinase II beta 2 (CaMK II beta 2 gene). AJ252236 - Homo sapiens mRNA for calcium/calmodulin dependent protein kinase II beta 1 (CaMK II beta 1 gene). BC019070 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta, mRNA (cDNA clone MGC:29528 IMAGE:5014712), complete cds. AK222703 - Homo sapiens mRNA for calcium/calmodulin-dependent protein kinase IIB isoform 2 variant, clone: CBR08526. AF112471 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta subunit mRNA, alternatively spliced, complete cds. AF112472 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta subunit mRNA, complete cds. U23460 - Human proline rich calmodulin-dependent protein kinase mRNA, complete cds. AF078803 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta subunit mRNA, complete cds. AF081572 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta e' subunit (CAMKB) mRNA, complete cds. AF081924 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta 6 subunit (CAMKB) mRNA, complete cds. AF083419 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta e subunit (CAMKB) mRNA, complete cds. AF140350 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta 7 subunit (CAM2) mRNA, complete cds. AM392749 - Synthetic construct Homo sapiens clone IMAGE:100002998 for hypothetical protein (CAMK2B gene). AM393817 - Synthetic construct Homo sapiens clone IMAGE:100002997 for hypothetical protein (CAMK2B gene). AJ252238 - Homo sapiens mRNA for calcium/calmodulin dependent protein kinase II beta 4 (CaMK II beta 4 gene). AK315663 - Homo sapiens cDNA, FLJ96755, Homo sapiens calcium/calmodulin-dependent protein kinase (CaMkinase) II beta (CAMK2B), transcript variant 5, mRNA. KJ905157 - Synthetic construct Homo sapiens clone ccsbBroadEn_14563 CAMK2B gene, encodes complete protein. KJ905158 - Synthetic construct Homo sapiens clone ccsbBroadEn_14564 CAMK2B gene, encodes complete protein. AM392792 - Synthetic construct Homo sapiens clone IMAGE:100002747 for hypothetical protein (CAMK2B gene). AM393562 - Synthetic construct Homo sapiens clone IMAGE:100002748 for hypothetical protein (CAMK2B gene). AB462968 - Synthetic construct DNA, clone: pF1KB8435, Homo sapiens CAMK2B gene for calcium/calmodulin-dependent protein kinase (CaM kinase) II beta, without stop codon, in Flexi system. CU676368 - Synthetic construct Homo sapiens gateway clone IMAGE:100019704 5' read CAMK2B mRNA. AB073352 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla00715, full insert sequence. AF131776 - Homo sapiens clone 25048 mRNA sequence. AK091991 - Homo sapiens cDNA FLJ34672 fis, clone LIVER2001164, highly similar to Human proline rich calmodulin-dependent protein kinase mRNA. AX747297 - Sequence 822 from Patent EP1308459. JD257879 - Sequence 238903 from Patent EP1572962. JD232709 - Sequence 213733 from Patent EP1572962. JD100747 - Sequence 81771 from Patent EP1572962. U50358 - Human calcium, calmodulin-dependent protein kinase II beta mRNA, partial cds. JD128981 - Sequence 110005 from Patent EP1572962.