Human Gene PIEZO1 (uc010cib.3)
Description: Homo sapiens piezo-type mechanosensitive ion channel component 1 (PIEZO1), mRNA.
RefSeq Summary (NM_001142864): The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015].
Transcript (Including UTRs)
Position: hg19 chr16:88,781,746-88,802,816 Size: 21,071 Total Exon Count: 26 Strand: -
Coding Region
Position: hg19 chr16:88,782,013-88,802,723 Size: 20,711 Coding Exon Count: 26
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: J3KQT3_HUMAN
DESCRIPTION: SubName: Full=Piezo-type mechanosensitive ion channel component 1; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR021999 - DUF3595
Pfam Domains: PF12166 - Piezo non-specific cation channel, R-Ras-binding domain
ModBase Predicted Comparative 3D Structure on J3KQT3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF384490 - JP 2014500723-A/191993: Polycomb-Associated Non-Coding RNAs.AK092007 - Homo sapiens cDNA FLJ34688 fis, clone MESAN2000711.AX747306 - Sequence 831 from Patent EP1308459.BC016983 - Homo sapiens family with sequence similarity 38, member A, mRNA (cDNA clone IMAGE:4186028), with apparent retained intron.BC008073 - Homo sapiens family with sequence similarity 38, member A, mRNA (cDNA clone IMAGE:3029644), complete cds.BC150271 - Homo sapiens family with sequence similarity 38, member A, mRNA (cDNA clone MGC:166873 IMAGE:9007243), complete cds.D87071 - Homo sapiens mRNA for KIAA0233 gene, complete cds.JD336225 - Sequence 317249 from Patent EP1572962.JD125392 - Sequence 106416 from Patent EP1572962.BC141877 - Homo sapiens cDNA clone IMAGE:40112012, containing frame-shift errors.JD339830 - Sequence 320854 from Patent EP1572962.AB161230 - Homo sapiens mRNA for Mib, complete cds.KC602455 - Homo sapiens PIEZO1 (PIEZO1) mRNA, complete cds.AB384448 - Synthetic construct DNA, clone: pF1KA0233, Homo sapiens FAM38A gene for FAM38A protein, complete cds, without stop codon, in Flexi system.KJ902019 - Synthetic construct Homo sapiens clone ccsbBroadEn_11413 PIEZO1 gene, encodes complete protein.LF375083 - JP 2014500723-A/182586: Polycomb-Associated Non-Coding RNAs.CU675919 - Synthetic construct Homo sapiens gateway clone IMAGE:100019131 5' read FAM38A mRNA.LF375084 - JP 2014500723-A/182587: Polycomb-Associated Non-Coding RNAs.LF375085 - JP 2014500723-A/182588: Polycomb-Associated Non-Coding RNAs.LF375087 - JP 2014500723-A/182590: Polycomb-Associated Non-Coding RNAs.LF375088 - JP 2014500723-A/182591: Polycomb-Associated Non-Coding RNAs.LF375090 - JP 2014500723-A/182593: Polycomb-Associated Non-Coding RNAs.LF375091 - JP 2014500723-A/182594: Polycomb-Associated Non-Coding RNAs.LF375092 - JP 2014500723-A/182595: Polycomb-Associated Non-Coding RNAs.LF375095 - JP 2014500723-A/182598: Polycomb-Associated Non-Coding RNAs.LF375096 - JP 2014500723-A/182599: Polycomb-Associated Non-Coding RNAs.LF375098 - JP 2014500723-A/182601: Polycomb-Associated Non-Coding RNAs.LF375099 - JP 2014500723-A/182602: Polycomb-Associated Non-Coding RNAs.LF375100 - JP 2014500723-A/182603: Polycomb-Associated Non-Coding RNAs.LF375114 - JP 2014500723-A/182617: Polycomb-Associated Non-Coding RNAs.LF375115 - JP 2014500723-A/182618: Polycomb-Associated Non-Coding RNAs.LF375116 - JP 2014500723-A/182619: Polycomb-Associated Non-Coding RNAs.LF375117 - JP 2014500723-A/182620: Polycomb-Associated Non-Coding RNAs.LF375119 - JP 2014500723-A/182622: Polycomb-Associated Non-Coding RNAs.LF375120 - JP 2014500723-A/182623: Polycomb-Associated Non-Coding RNAs.LF375121 - JP 2014500723-A/182624: Polycomb-Associated Non-Coding RNAs.LF375122 - JP 2014500723-A/182625: Polycomb-Associated Non-Coding RNAs.JD119580 - Sequence 100604 from Patent EP1572962.MA620067 - JP 2018138019-A/191993: Polycomb-Associated Non-Coding RNAs.MA610660 - JP 2018138019-A/182586: Polycomb-Associated Non-Coding RNAs.MA610661 - JP 2018138019-A/182587: Polycomb-Associated Non-Coding RNAs.MA610662 - JP 2018138019-A/182588: Polycomb-Associated Non-Coding RNAs.MA610664 - JP 2018138019-A/182590: Polycomb-Associated Non-Coding RNAs.MA610665 - JP 2018138019-A/182591: Polycomb-Associated Non-Coding RNAs.MA610667 - JP 2018138019-A/182593: Polycomb-Associated Non-Coding RNAs.MA610668 - JP 2018138019-A/182594: Polycomb-Associated Non-Coding RNAs.MA610669 - JP 2018138019-A/182595: Polycomb-Associated Non-Coding RNAs.MA610672 - JP 2018138019-A/182598: Polycomb-Associated Non-Coding RNAs.MA610673 - JP 2018138019-A/182599: Polycomb-Associated Non-Coding RNAs.MA610675 - JP 2018138019-A/182601: Polycomb-Associated Non-Coding RNAs.MA610676 - JP 2018138019-A/182602: Polycomb-Associated Non-Coding RNAs.MA610677 - JP 2018138019-A/182603: Polycomb-Associated Non-Coding RNAs.MA610691 - JP 2018138019-A/182617: Polycomb-Associated Non-Coding RNAs.MA610692 - JP 2018138019-A/182618: Polycomb-Associated Non-Coding RNAs.MA610693 - JP 2018138019-A/182619: Polycomb-Associated Non-Coding RNAs.MA610694 - JP 2018138019-A/182620: Polycomb-Associated Non-Coding RNAs.MA610696 - JP 2018138019-A/182622: Polycomb-Associated Non-Coding RNAs.MA610697 - JP 2018138019-A/182623: Polycomb-Associated Non-Coding RNAs.MA610698 - JP 2018138019-A/182624: Polycomb-Associated Non-Coding RNAs.MA610699 - JP 2018138019-A/182625: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: BC141877, J3KQT3, J3KQT3_HUMAN, NM_001142864, NP_001136336UCSC ID: uc010cib.3RefSeq Accession: NM_001142864
Protein: J3KQT3
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
BC141877.1
exon count:
26 CDS single in 3' UTR:
no
RNA size:
4202
ORF size:
4155 CDS single in intron:
no
Alignment % ID:
99.88
txCdsPredict score:
8300.00 frame shift in genome:
no
% Coverage:
99.43
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.