Gene interactions and pathways from curated databases and text-mining
J Immunol 2002, PMID: 11994435

Expression of CD94/NKG2-A on human T lymphocytes is induced by IL-12: implications for adoptive immunotherapy.

Derre, Laurent; Corvaisier, Murielle; Pandolfino, Marie-Christine; Diez, Elisabeth; Jotereau, Francine; Gervois, Nadine

NK cell receptors (NKRs) are expressed on a subset of human T cells, predominantly CD8(+), within which they can modulate TCR-mediated functions. In an attempt to identify the mechanisms leading to NKR expression, we analyzed the capacity of IL-12 to modulate the expression by T cells of the components of the CD94/NKG2-A inhibitory receptor, a member of the C-type lectin-like family of NKR. We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8(+) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15. We also show, using the redirected killing assay, that IL-12-induced expression of both CD94 and NKG2-A led to the acquisition by T cells of a functional inhibitory receptor. Expression of the CD94/NKG2-A inhibitory receptor was also induced by IL-12 during T cell Ag stimulation so that in the presence of this cytokine a high proportion of melanoma-reactive CTL induced from PBL by melanoma peptide stimulation expressed this receptor. This study emphasizes the implication of IL-12 in the modulation of immune responses through NKR induction.

Diseases/Pathways annotated by Medline MESH: Melanoma
Document information provided by NCBI PubMed

Text Mining Data

IL-12 → CD94/NKG2-A: " Expression of CD94/NKG2-A on human T lymphocytes is induced by IL-12 : implications for adoptive immunotherapy "

CD94/NKG2-A → IL-12: " Expression of CD94/NKG2-A on human T lymphocytes is induced by IL-12 : implications for adoptive immunotherapy "

IFN-gamma → IL-12: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

IL-12 → IL-15: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

NKG2-A → IFN-gamma: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

NKG2-A → IL-12: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

NKG2-A → IL-15: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

CD94 → IFN-gamma: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

CD94 → IL-12: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

CD94 → IL-15: " We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15 "

NKG2-A → IL-12: " We also show, using the redirected killing assay, that IL-12 induced expression of both CD94 and NKG2-A led to the acquisition by T cells of a functional inhibitory receptor "

CD94 → IL-12: " We also show, using the redirected killing assay, that IL-12 induced expression of both CD94 and NKG2-A led to the acquisition by T cells of a functional inhibitory receptor "

Manually curated Databases

No curated data.