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Src → TGF-beta1: " Here, we show that 1 ) KTI suppressed TGF-beta1 induced phosphorylation of Src , ERK1/2, and Akt by 40-60 % ; 2 ) KTI was insensitive to suppress the phosphorylation of ERK1/2 and Akt in the constitutively active ( CA ) -c-Src ( Y529F ) cells ; 3 ) uPA expression was up-regulated in TGF-beta1 stimulated HRA cells and in unstimulated Y529F cells ; 4 ) the addition of KTI reduced the TGF-beta1 induced increase of uPA gene and protein expression in the wild-type c-Src transfected cells ( in contrast, KTI could not inhibit uPA expression in the Y529F cells ) ; and 5 ) CA-c-Src transfection resulted in a 2-fold increase in invasiveness, whereas KTI did not reduce invasion of the Y529F cells "
ERK1/2 → TGF-beta1: " Here, we show that 1 ) KTI suppressed TGF-beta1 induced phosphorylation of Src, ERK1/2 , and Akt by 40-60 % ; 2 ) KTI was insensitive to suppress the phosphorylation of ERK1/2 and Akt in the constitutively active ( CA ) -c-Src ( Y529F ) cells ; 3 ) uPA expression was up-regulated in TGF-beta1 stimulated HRA cells and in unstimulated Y529F cells ; 4 ) the addition of KTI reduced the TGF-beta1 induced increase of uPA gene and protein expression in the wild-type c-Src transfected cells ( in contrast, KTI could not inhibit uPA expression in the Y529F cells ) ; and 5 ) CA-c-Src transfection resulted in a 2-fold increase in invasiveness, whereas KTI did not reduce invasion of the Y529F cells "
Akt → TGF-beta1: " Here, we show that 1 ) KTI suppressed TGF-beta1 induced phosphorylation of Src, ERK1/2, and Akt by 40-60 % ; 2 ) KTI was insensitive to suppress the phosphorylation of ERK1/2 and Akt in the constitutively active ( CA ) -c-Src ( Y529F ) cells ; 3 ) uPA expression was up-regulated in TGF-beta1 stimulated HRA cells and in unstimulated Y529F cells ; 4 ) the addition of KTI reduced the TGF-beta1 induced increase of uPA gene and protein expression in the wild-type c-Src transfected cells ( in contrast, KTI could not inhibit uPA expression in the Y529F cells ) ; and 5 ) CA-c-Src transfection resulted in a 2-fold increase in invasiveness, whereas KTI did not reduce invasion of the Y529F cells "
ERK1/2 → TGF-beta1: " Here, we show that 1 ) KTI suppressed TGF-beta1 induced phosphorylation of Src, ERK1/2 , and Akt by 40-60 % ; 2 ) KTI was insensitive to suppress the phosphorylation of ERK1/2 and Akt in the constitutively active ( CA ) -c-Src ( Y529F ) cells ; 3 ) uPA expression was up-regulated in TGF-beta1 stimulated HRA cells and in unstimulated Y529F cells ; 4 ) the addition of KTI reduced the TGF-beta1 induced increase of uPA gene and protein expression in the wild-type c-Src transfected cells ( in contrast, KTI could not inhibit uPA expression in the Y529F cells ) ; and 5 ) CA-c-Src transfection resulted in a 2-fold increase in invasiveness, whereas KTI did not reduce invasion of the Y529F cells "