Gene interactions and pathways from curated databases and text-mining
FEBS Lett 2005, PMID: 16263121

A proteomic snapshot of the human heat shock protein 90 interactome.

Falsone, S Fabio; Gesslbauer, Bernd; Tirk, Florian; Piccinini, Anna-Maria; Kungl, Andreas J

Heat shock protein 90 (Hsp90) is a molecular chaperone which modulates several signalling pathways within a cell. By applying co-immunoprecipitation with endogeneous Hsp90, we were able to identify 39 novel protein interaction partners of this chaperone in human embryonic kidney cells (HEK293). Interestingly, levels of DNA-activated protein kinase catalytic subunit, an Hsp90 interaction partner found in this study, were found to be sensitive to Hsp90 inhibitor treatment only in HeLa cells but not in HEK293 cells referring to the tumorgenicity of this chaperone.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: GAPDH — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PSMD1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TCP1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPL7 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: UBA1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MDH1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSPA1A — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MTHFD1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSP90AB1 — SPTAN1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSP90AB1 — XPO1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PRKDC — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NANS — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EEF2 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPS3A — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPS4X — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: LDHA — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPS6 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSPA1A — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PRKDC — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PGK1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: GAPDH — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYH9 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSPH1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ACTN1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TCP1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: UBA1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MTHFD1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IARS2 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C12orf10 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPSA — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PKM — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSP90AA1 — FLNA (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FASN — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALDOA — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C12orf10 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NANS — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: XPO1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NUMA1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PSAT1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ACTG1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSP90AA1 — GNAI2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPS4X — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: LDHA — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EEF2 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EIF3H — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: AARS — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PSMB5 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SPTAN1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MDH1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PSMD1 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPL5 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPL7 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPLP0 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TPM3 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TPM3 — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ACTG1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EIF3H — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYH9 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PSMB5 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPL5 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ACTN1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PSAT1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSP90AB1 — RPLP0 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NUMA1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PGK1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSP90AB1 — GNAI2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PKM — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPS3A — HSP90AA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALDOA — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPS6 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IARS2 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FASN — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: AARS — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSP90AB1 — FLNA (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSPH1 — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPSA — HSP90AB1 (physical association, affinity chromatography technology)
  • IRef Hprd Interaction: Complex of 1561 proteins (in vivo)
  • IRef Intact Interaction: Complex of 41 proteins (association, anti bait coimmunoprecipitation)
In total, 818 gene pairs are associated to this article in curated databases