Genesis 2007,
PMID: 17410548
Kreslova, Jana; Machon, Ondrej; Ruzickova, Jana; Lachova, Jitka; Wawrousek, Eric F; Kemler, Rolf; Krauss, Stefan; Piatigorsky, Joram; Kozmik, Zbynek
beta-Catenin plays a key role in cadherin-mediated cell adhesion as well as in canonical Wnt signaling. To study the role of beta-catenin during eye development, we used conditional Cre/loxP system in mouse to inactivate beta-catenin in developing lens and retina. Inactivation of beta-catenin does not suppress lens fate, but instead results in abnormal morphogenesis of the lens. Using BAT-gal reporter mice, we show that beta-catenin-mediated Wnt signaling is notably absent from lens and neuroretina throughout eye development. The observed defect is therefore likely due to the cytoskeletal role of beta-catenin, and is accompanied by impaired epithelial cell adhesion. In contrast, inactivation of beta-catenin in the nasal ectoderm, an area with active Wnt signaling, results in formation of crystallin-positive ectopic lentoid bodies. These data suggest that, outside of the normal lens, beta-catenin functions as a coactivator of canonical Wnt signaling to suppress lens fate.
Diseases/Pathways annotated by Medline MESH: Choristoma, Nose Diseases
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Text Mining Data
Wnt → cadherin: "
beta-Catenin plays a key role in
cadherin mediated cell adhesion as well as in canonical
Wnt signaling
"
Wnt — beta-Catenin: "
beta-Catenin plays a key role in cadherin mediated cell adhesion as well as in canonical Wnt signaling
"
Wnt → beta-catenin: "
Using BAT-gal reporter mice, we show that beta-catenin mediated Wnt signaling is notably absent from lens and neuroretina throughout eye development
"
Manually curated Databases
No curated data.