Hama et al., Biochem Biophys Res Commun 2006
(Fibrosis) :
Furthermore, Ang II rapidly induced inhibitory Smad7 mRNA expression
Zhang et al., Hypertension 2010
(Fibrosis...) :
Enhanced upregulation of the Ang II type I receptor and activation of the transforming growth factor-beta/Smad and nuclear factor-kappaB signaling pathways may be the mechanisms by which CRP promotes cardiac fibrosis and inflammation under high Ang II conditions
Yang et al., J Pathol 2010
(Kidney Diseases) :
In contrast, over-expression of Smad7 inhibited Ang II-induced Smad2/3 activation and EMT in NRK52E cells and in a rat model of remnant kidney disease