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IGF2 — MAPK8
Text-mined interactions from Literome
Gingras et al., Mol Endocrinol 2000
(Breast Neoplasms) :
Wortmannin also blocked
MAPK activation by IL-4,
IGF-I , and insulin, suggesting that the MAPK cascade acts as a downstream effector of PI 3-kinases
Ahmad et al., Cell Signal 2000
:
Furthermore,
IGF-1 dependent stimulation of p42/p44
MAPK and PDE3B was abolished in serum deprived cells and this was associated with apoptosis
Pozios et al., Am J Physiol Regul Integr Comp Physiol 2001
(MAP Kinase Signaling System) :
These results indicate that both
IGF-I and -II are potent mitogens for zebrafish embryonic cells and that activation of both the
MAPK and PI3 kinase signaling pathways is
required for the mitogenic action of IGFs in zebrafish embryonic cells
Sumitomo et al., Cancer Res 2001
(Prostatic Neoplasms) :
Incubation of TSU-Pr1 cells with specific kinase inhibitors together with ET-1 or bombesin showed that
IGF-IR activation is required for neuropeptide induced Akt phosphorylation, and that neuropeptide induced Akt activation is predominantly
mediated by Src and phosphatidylinositol 3-kinase but not by
mitogen activated protein kinase or protein kinase C
Klotz et al., J Biol Chem 2002
:
In addition,
IGF-1 stimulated phosphorylation of uterine Akt and
MAPK in both WT and alpha ERKO mice
Gilmore et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
Moreover, we demonstrate that
IGF transactivates the EGF receptor and that ZD1839
blocks IGF mediated phosphorylation of
MAPK and BAD
Yamagishi et al., Brain Res Mol Brain Res 2003
(Potassium Deficiency) :
Comparison of inhibitory
effects of brain derived neurotrophic factor and
insulin-like growth factor on low potassium induced apoptosis and activation of p38
MAPK and c-Jun in cultured cerebellar granule neurons
Sirotkin et al., J Reprod Dev 2003
(MAP Kinase Signaling System) :
For this purpose, we studied the influence of
IGF-II ( 0,1,10 or 100 ng/ml ),
inhibitors of TK ( AG1024, 1 microg/ml ),
MAPK ( PD98059, 5 microg/ml ), and their combinations, on proliferation ( expression of proliferation related substances PCNA ), apoptosis ( apoptosis associated protein bax ), TK ( phosphotyrosine ), MAPK ( ERK1,2 ), cyclin dependent protein kinase 2 ( p34/cdc2 ) and transcription factor CREB-1, as well as on the release of progesterone ( P ), testosterone ( T ), estradiol ( E ) and arginine-vasotocin ( AVT ) in cultured fragments of ovarian follicles
Kataoka et al., J Radiat Res 2004
:
We have investigated the
role of insulin-like growth factor I receptor (
IGF-IR ) in heat shock induced activation of the
mitogen activated protein kinase ( MAPK ) and phosphatidylinositol-3 ' kinase (PI3-K) pathways
De Robertis et al., Annu Rev Cell Dev Biol 2004
:
Neural induction by anti-BMPs such as Chordin requires
mitogen activated protein kinase ( MAPK ) activation
mediated by FGF and
IGF
Itakura et al., J Neurochem 2005
:
In striking contrast,
IGF-1 activated the PI3-kinase pathway but not the MAPK pathway, and IGF-1 dependent enhancement was
suppressed by a PI3-kinase inhibitor but not by a
MAPK kinase inhibitor
Allen et al., Cancer Res 2007
(Neoplasms) :
IGF-IR expression is shown for a diverse cohort of cell lines, whereas targeted IGF-IR blockade by A12 inhibits
IGF-IR phosphorylation and
activation of the downstream effectors Akt and
mitogen activated protein kinase
Barnes et al., Clin Cancer Res 2007
(Head and Neck Neoplasms) :
Pretreatment of serum starved 183A or TU159 SCCHN cell lines with A12 ( 10 microg/mL ) blocked
IGF stimulated activation of IGF-IR, insulin receptor substrate (IRS)-1 and IRS-2,
mitogen activated protein kinase , and phosphatidylinositol 3-kinase
Hiden et al., Diabetes 2008
(Abortion, Spontaneous...) :
The insulin effect was dependent on phosphatidylinositol 3-kinase, the IGF-I
effect on
mitogen activated protein kinase , and the
IGF-II effect on both
Brady et al., Growth Horm IGF Res 2008
:
IGF-I and -II caused significant increases in PI3-K, but not
MAPK , activity
Codina et al., Gen Comp Endocrinol 2008
:
Metabolic and mitogenic effects of IGF-II in rainbow trout ( Oncorhynchus mykiss ) myocytes in culture and the
role of
IGF-II in the PI3K/Akt and
MAPK signalling pathways ...
IGF-II stimulated the phosphorylation of the protein
MAPK , especially at the proliferation stage ( increases of up to 125.7+/-16.9 % and 125.3+/-3.3 % with respect to control in IGF-II- and IGF-I treated cells, respectively )
Xi et al., Mol Endocrinol 2008
:
In addition,
IGF-I dependent
MAPK activation was also impaired, and SMC proliferation in response to IGF-I was inhibited
Singh et al., Am J Physiol Gastrointest Liver Physiol 2010
:
Surprisingly, curcumin was almost ineffective in reducing
IGF-II stimulated activation of
p38MAPK but significantly reduced progastrin stimulated phosphorylation of p38
Lovett et al., Endocrinology 2010
:
Essential
role for p38alpha
MAPK but not p38gamma MAPK in
Igf2 expression and myoblast differentiation ... p38
MAPK signaling is
essential for myoblast differentiation and in particular for up-regulation of promyogenic
Igf2 expression
Li et al., Cancer 2011
(Neovascularization, Pathologic...) :
IGF-IR/dn reduced VEGF expression,
reduced the activation of both protein kinase B ( Akt ) and
mitogen activated protein kinase ( MAPK ), and reduced vascular formation, indicating that IGF-IR/dn inhibited tumor growth in mice by inhibiting both angiogenesis and lymphangiogenesis
Jiang et al., Am J Physiol Endocrinol Metab 2011
(MAP Kinase Signaling System) :
In carp pituitary cells,
IGF-I and -II could
induce rapid phosphorylation of IGF-I receptor, MEK1/2, ERK1/2, MKK3/6, and p38
MAPK ; and SLa and SLß secretion, protein production, and mRNA expression caused by IGF-I and -II stimulation were negated by inactivating MEK1/2 and p38 MAPK ... In carp pituitary cells,
IGF-I and -II could
induce rapid phosphorylation of IGF-I receptor, MEK1/2, ERK1/2, MKK3/6, and p38
MAPK ; and SLa and SLß secretion, protein production, and mRNA expression caused by IGF-I and -II stimulation were negated by inactivating MEK1/2 and p38 MAPK
Jiao et al., Mol Cell Biochem 2013
(MAP Kinase Signaling System) :
In addition, Akt, Erk1/2
MAPK , and p38 MAPK pathways were also
involved in the regulation of basal levels of IGF-I and
IGF-II genes during myogenesis
Cheng et al., J Biol Chem 1998
:
Finally,
IGF-I inhibition of JNK phosphorylation was
blocked by the
mitogen activated protein kinase/extracellular signal regulated kinase inhibitor, PD98059