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Batsi et al., Biochem Pharmacol 2009
:
Interestingly, NF-kappaB activity and p50 levels were increased by 2-ME2 and suppression of NF-kappaB signaling reduced p27 ( Kip1 ) expression and sensitized cells to 2-ME2 induced apoptosis
Parrondo et al., Molecular cancer 2010
(Prostatic Neoplasms) :
In castration-resistant DU145 and PC3 cells, Doc and 2ME2 had little effect on the high basal NF-kappaB activity and addition of parthenolide did not enhance cell death