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CASP5 — STX1A
Text-mined interactions from Literome
Kojio et al., FEMS Immunol Med Microbiol 2000
:
The findings suggest that
Stx1 as well as Stx2
activate caspase-3 , which plays a critical role in apoptosis, and that the apoptotic signals rise after Stx is transported to the Golgi apparatus
Kiyokawa et al., J Cell Biochem 2001
(Burkitt Lymphoma) :
Although the precise mechanism of
Stx1 mediated activation of
caspase-8 is still unclear, we have demonstrated that crosslinkage of CD77, a functional receptor for Stx1, with specific antibody is sufficient to induce activation of caspase-8
Ching et al., Infect Immun 2002
:
Cleavage of
caspase-9 and the proapoptotic member of the Bcl-2 family BID was also
induced by
Stx1 , as determined by immunoblot analyses
Talukder et al., Microb Pathog 2012
:
Inhibition of
caspase-3 reduced
STX-1 induced phosphorylation of H2AX and nuclear condensation