UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin/RAGE/HMGB1 complex (ITGAM-ITGB2-AGER-HMGB1) → NF kappa B1 (NFKB1) (modification, activates) Pullerits et al., Arthritis Rheum 2006 *, Orlova et al., EMBO J 2007
Evidence: mutant phenotype, assay
NCI Pathway Database amb2 Integrin signaling: RAGE (AGER) → alphaM/beta2 Integrin/RAGE/HMGB1 complex (ITGAM-ITGB2-AGER-HMGB1) (modification, collaborate)
Chavakis et al., J Exp Med 2003 *, Orlova et al., EMBO J 2007
Evidence: physical interaction
NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin/RAGE/HMGB1 complex (ITGAM-ITGB2-AGER-HMGB1) → HMGB1 (HMGB1) (modification, collaborate) Chavakis et al., J Exp Med 2003 *, Orlova et al., EMBO J 2007
Evidence: physical interaction
NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin/RAGE/HMGB1 complex (ITGAM-ITGB2-AGER-HMGB1) → alphaM/beta2 Integrin complex (ITGAM-ITGB2) (modification, collaborate)
Chavakis et al., J Exp Med 2003 *, Orlova et al., EMBO J 2007
Evidence: physical interaction
NCI Pathway Database amb2 Integrin signaling: HMGB1 (HMGB1) → alphaM/beta2 Integrin complex (ITGAM-ITGB2) (modification, collaborate)
Chavakis et al., J Exp Med 2003 *, Orlova et al., EMBO J 2007
Evidence: physical interaction