Gene interactions and pathways from curated databases and text-mining

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IL1RN — PTGS2

Text-mined interactions from Literome

La et al., Mol Carcinog 2001 (Carcinoma, Squamous Cell...) : In icIL-1Ra-JWF2 cells, however, cyclooxygenase-2 mRNA levels were dramatically reduced and shown to be transcriptionally regulated by icIL-1Ra
Palmer et al., Arthritis Res Ther 2004 : Indomethacin increased IL-1beta induced IL-1Ra secretion in synovial fibroblasts and de-differentiated chondrocytes, suggesting that inhibition of COX-2 may indeed enhance IL-1beta induced IL-1Ra production
ViganĂ² et al., Am J Respir Crit Care Med 1997 : COX-2 expression and PGE2 formation were inhibited by dexamethasone ( 2 microM ), cycloheximide ( 10 microM ), and IL-1-receptor antagonist (IL-1 ra) ( 250 ng/ml ), independently
Kniss et al., Am J Obstet Gynecol 1997 : Experiments were conducted to examine whether interleukin-1 receptor antagonist could suppress interleukin-1 induced cyclooxygenase-2 expression ... Northern and Western analyses revealed that interleukin-1 receptor antagonist blocked interleukin-1 alpha induced expression of cyclooxygenase-2 messenger ribonucleic acid transcripts and the subsequent appearance of cyclooxygenase-2 protein